摘要
目的了解Caspase家族及其与细胞凋亡关系的研究进展。方法复习国内外相关文献,综述Caspase家族成员、功能、激活、调节及其在细胞凋亡中的作用。结果Caspase不仅与真核细胞凋亡密切相关,还参与了细胞因子的成熟、细胞生长和分化。结论Caspase在介导细胞凋亡中起重要作用。对Caspase的结构、特性及生理作用研究的不断深入,有助于研究细胞凋亡机制,为肿瘤和许多慢性疾病的防治和药物开发提供更多选择。
Objective To investigate the recent advances of relationship between caspase families and apoptosis.Methods Reviewing the achievements about caspase families,this paper tries to summarize the caspase families function,caspase activation, regulation and it's role in cell apoptosis.Results Caspases not only correlate with cell apoptosis intensively, but also contribute to cytokine maturation,cell growth and differentiation.Conclusion Caspases play an important role in cell apoptosis. Advanced on caspases structure,characteristics and it's biological functions will contribute to elucidate mechanisms of apoptosis and find more methods of prevention and therapy on tumor and many chronic diseases as well as the development of new medicines.
出处
《新乡医学院学报》
CAS
2005年第1期67-70,共4页
Journal of Xinxiang Medical University
