摘要
目的 :观察锌 (Zn)、维生素 A (VA)、维生素 B2 (VB2 )缺乏和强化补充后对初断乳大鼠血清、心肌线粒体超氧化物歧化酶活性的影响。方法 :通过耗竭方式造成初断乳大鼠的 Zn、 VA、 VB2 单独和联合缺乏模型后强化补充相应营养素。造模成功及干预结束后 ,测血清和心肌线粒体总超氧化物歧化酶 (T- SOD)活性。结果 :Zn、 VA、 VB2 缺乏和补充对大鼠血清 T- SOD活性无明显影响 ,而 VB2 缺乏和 3种营养素联合缺乏可致心肌线粒体 T- SOD活性显著降低 ,单独补充 VA、 VB2 和 3种营养素联合补充可致大鼠心肌线粒体 T- SOD活性显著增加。结论 :Zn、 VA、 VB2 缺乏对初断乳大鼠心肌线粒体 T- SOD活性有明显影响 ,提示重视婴幼儿期 Zn、 VA、 VB2 营养具有重要的意义。
Objective:To evaluate the effect of Zinc(Zn), vitamin A(VA) and riboflavin(VB 2) alone or combined deficiency and supplement on serum and myocardial mitochondrial superoxide dismutase (SOD) activity of weanling rats.Methods:Zn,VA and VB 2 alone or combined deficiency were induced by nutrient depletion, and subsequent repleted with appropriate nutrient supplement. After intervention, serum and myocardial mitochondrial total SOD (T-SOD) activity were detected.Results:Decreased myocardial mitochondrial T-SOD activity caused by VA and VB 2 alone or combined deficiency for three nutrients in rats were observed. After supplement of these nutrients, myocardial mitochondrial T-SOD activity were increased significantly.Conclusion:Zn, VA and VB 2 deficiency in rats can reduce myocardial mitochondrial SOD activity, and it is suggested that the deficiency of these nutrients may influence growth and developments of infant and young children.
出处
《现代预防医学》
CAS
2004年第5期690-691,694,共3页
Modern Preventive Medicine
