摘要
小鼠灌胃染毒醋酸铅 10mg/kg、2 0mg/kg和 40mg/kg ,1次 /d ,连续染毒 5d ,测定精子数、精子活动度、精子畸形率和初级精母细胞染色体畸变率。结果显示染毒 2 0mg/kg以上时 ,精子计数、直线运动精子数、活精子率随染毒剂量增加而下降 ,而静止不动精子数、精子畸形率和初级精母细胞染色体畸变率随剂量增加而升高 ,各指标与阴性对照组比较差异均有显著性或高度显著性 (P <0 0 5 ,P <0 0 1) ,并呈明确的剂量 反应关系 ,r值依次为 -0 7866,-0 8949,-0 780 9,0 780 9,0 5 5 81,0 493 2 (P <0 0 1,P <0 0 5 )。说明染毒醋酸铅≥ 2 0mg/kg可损害小鼠的生精功能。
Mice were continuously given lead acetate at doses of 10 mg/kg,20 mg/kg and 40 mg/kg,respectively,once a day for 5 days,by gavage,a nd cou nt,motility,deformity of the sperm and chromosome aberration of primary spermat o cyte were determined.Result showed that count of sperm,number of sperm moving strai ghtly and its viability decreased with increase of doses of lead acetate in the mice exposed to 20 mg/kg or over of lead acetate,while count of inactive sperm, d eformity of sperm and chromosome aberration rate of primary spermatocyte increas ed with increase of doses of lead acetate,all significantly different from those in the control group(P<0.05 or P<0.01),in a dose-re sponse relationship,with r=-0.786 6,-0.894 9,-0.780 9 ,0.780 9,0.558 1 and 0.493 2,respectively (P<0.01 or P<0.05).It indicated t hat exposure to lead acetate at a dose of 20mg/kg or above by gavage could damag e spermiogenesis in mice.
出处
《中国工业医学杂志》
CAS
北大核心
2004年第5期315-317,共3页
Chinese Journal of Industrial Medicine
关键词
醋酸铅
小鼠
生精功能
初级精母细胞染色体畸变
Lead acetate
Mice
Spermiogenesis
Chromosome a berration of primary spermatocyte
