摘要
目的 比较尿激酶动、静脉溶栓治疗急性脑梗死的疗效和安全性。方法 5 0例急性脑梗死 (发病≤ 8h)患者分为动脉溶栓、静脉溶栓治疗组和对照组。采用美国国立卫生院神经功能缺失评分表 (NIHSS)于治疗前 ,治疗后 2 4h、1周、2周记录神经功能缺损程度。对临床症状恶化者复查头颅CT ,明确症状性颅内出血的发生率。结果 尿激酶溶栓治疗后 2 4h治疗组NIHSS低于对照组 (P <0 0 5 ) ,1周后差异更加显著(P <0 0 1) ,但溶栓治疗组之间 (经动脉或静脉溶栓 )NIHSS差异无显著意义 (P >0 0 5 )。三组症状性颅内出血的发生率分别为 6 6 7%、9 5 2 %和 14 2 9% ,无统计学差异 (P >0 0 5 )。结论 尿激酶溶栓治疗急性脑梗死疗效确切、安全 。
Objective To compare efficacy and safety of intra arterial and intravenous urokinase(UK) thrombolytic therapy for acute cerebral infaction.Methods 50 acute cerebral infaction patients(≤8 hours of symptom onset) were divided into intra arterial,intravenous thrombolytic therapy group and control group.Neurological deficits of baseline and 1 week,2 weeks after thrombolytic therapy were recorded with U.S. National Institues Of Health Stroke Scale(NIHSS).Deteriorative patients of clinical symptom were repeated cranial CT scan to define symptomatic intracerebral hemorrhage rate.Results NIHSS was significantly lower compared with the control group after 24 hours of thrombolytic therapy(P<0.05).This difference was even more significant more differently after 1 week(P<0.01).But there wasn't significant difference between the thrombolysis groups(P>0.05).Symptomatic intracerebral hemorrhage rates of the three groups were 6.67%,9.52% and 14.29%(P>0.05).Conclusion Thrombolytic therapy with UK was effective and safe for acute cerebral infaction,intra arterial thrombolytic therapy was not better than intravenous therapy.
出处
《中国基层医药》
CAS
2004年第10期1176-1177,共2页
Chinese Journal of Primary Medicine and Pharmacy
