摘要
目的 研究心脑血管基础疾病与严重急性呼吸综合征(SARS)患者与SARS病情和发生多器官功能障碍综合征(MODS)的关系。方法 分析2003年北京市1291例SARS患者的病历资料,分别用卡方检验和Logistic回归分析比较既往无基础疾病、有其他基础疾病和有心脑血管基础疾病3组SARS患者重症患者所占比例和MODS的发生率。结果 SARS患者总的重症构成比和MODS的发生率分别是34.86％和13.71％。既往无基础病、有其他基础病和有心脑血管病的SARS患者重症构成比和MODS发生率分别为28.10％、43.70％、58.18％和9.83％、18.52％、27.27％。3组比较差异均有显著意义(P<0.0001)。Logistic回归分析表明,在调整年龄和职业后,合并有心脑血管病的患者发生重症SARS和MODS的危险分别是无基础病者的1.819倍和1.974倍(OR=1.819,95％可信区间=1.276-2.592;OR=1.974,95％可信区间=1.273-3.060),差异均有显著意义(P<0.05)。结论 心脑血管基础疾病是SARS患者病情演化成发生重症和MODS的重要危险因素。
Objective To investigate the effects of underlying cerebrocardiovascular diseases on the incidence of critical conditions and multiple organs dysfunction syndrome (MODS) among the severe acute respiratory syndrome ( SARS) cases. Methods A database of all SARS cases in Beijing in 2003 was established and the data of 1291 cases whose data were complete among them was analyzed. The effects of cerebrocardiovascular diseases, other comorbid diseases and absence of underlying diseases on the incidence of critical conditions and MODS in SARS cases were compared with chi-square test and logistic regression analysis. Results The incidence rates of critical conditions and MODS in SARS cases were 34. 86% and 13.71% respectively. The incidence rates of critical conditions and MODS among the SARS cases without underlying diseases, with other comorbid diseases, and with cerebrocardiovascular diseases were 28. 10% , 43. 70% , and 58. 18% , and 9. 83% , 18. 52% , and 27. 27% respectively. The differences among the three groups were all statistically significant ( all P < 0. 0001) . Logistic regression analysis showed that presence of cerebrocardiovascular diseases in SARS patients was independently associated with the risks of critical conditions and MODS in comparison with those without underlying diseases after adjusting for age and occupation. [odds ratio (OR) =1.819, 95% CI = 1. 276 - 2. 592, and OR = 1. 974, 95% CI = 1. 273 -3.060 respectively]. Conclusion The SARS cases with cerebrocardiovascular diseases have the highest incidence rate of critical conditions and MODS. Presence of Cerebrocardiovascular diseases is an important risk factor for critical conditions and MODS in the SARS cases.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2004年第15期1257-1259,共3页
National Medical Journal of China
基金
国家863课题资助项目(2003AA208107)
