摘要
目的分析新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者的临床特点,为临床诊疗提供帮助。方法将2020-01/2020-03月作者医院收治的224例新型冠状病毒(SARS-CoV-2)核酸检测阳性的COVID-19确诊患者作为研究对象。按临床分型诊断,将其分为普通型组和(危)重型组。观察两组患者的一般临床特点和入院后首次实验室检查指标特点。结果两组患者的性别比例、基础疾病及发病症状差异有统计学意义(P均<0.05)。(危)重型组较普通型组白细胞(white blood cell,WBC)、中性粒细胞计数(neutrophils,NEU)、C-反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)、白细胞介素6(interleukin 6,IL-6)、凝血酶原时间(prothrombin time,PT)、D-二聚体(D-dimers,D-D)、纤维蛋白原(fibrinogen,Fg)、天门冬氨酸氨基转移酶(alanine aminotransferase,ALT)、丙氨酸氨基转移酶(aspartate aminotransferase,AST)、肌酐(creatinine,Cr)、磷酸肌酸激酶(creatine phosphokinase,CPK)、肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、乳酸脱氢酶(lactate dehydrogenase,LDH)显著增高(P均<0.05);(危)重型组淋巴细胞计数(lymphocytes,LYM)、血小板计数(platelets,PLT)低于普通型组(P均<0.05)。结论年龄和基础疾病是影响COVID-19患者病情的重要因素。动态监测患者的血常规、炎性指标、凝血功能、生化等数值,有助于评估患者的病情,为临床诊疗工作提供参考依据。
Objective To analyze the clinical characteristics of patients with coronavirus disease 2019(COVID-19)and provide assistance for clinical diagnosis and treatment.Methods A total of 224 confirmed COVID-19 patients with positive nucleic acid test of SARS-CoV-2 in authors′hospital from January 2020 to March 2020 were enrolled.All patients were divided into the mild group and the(critical)severe group by clinical diagnosis.The general clinical characteristics and the data of laboratory examination on admission of these two groups patients were observed.Results There were significant differences in sex ratio,basic diseases and symptoms between the two groups patients(all P<0.05).The(critical)severe patients possessed higher indicators such as white blood cell count(WBC),neutrophil count(NEU),C-reactive protein(CRP),procalcitonin(PCT)and interleukin 6(IL-6),prothrombin time(PT),D-dimer(D-D)and fibrinogen(Fg),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),creatine phosphokinase(CPK),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)compared with patients in the mild group(all P<0.05).The lymphocyte count(LYM)and platelet count(PLT)of patients in the(critical)severe group were lower than those of patients in the mild group(all P<0.05).Conclusion Age and basic diseases are important factors affecting COVID-19 patients′conditionns.Dynamic monitoring of the patient′s blood routine,inflammatory indicators,coagulation function,biochemical and other values is helpful to evaluate the patient′s condition and provide reference for clinical diagnosis and treatment.
作者
郑娅琼
刘磊
蔡李平
吴万磊
唐诗
张艳红
郑山根
ZHENG Yaqiong;LIU Lei;CAI Liping;WU Wanlei;TANG Shi;ZHANG Yanhong;ZHENG Shangen(Department of Transfusion,General Hospital of Central Theater Command,Wuhan Hubei 430070,China)
出处
《华南国防医学杂志》
CAS
2020年第6期412-415,共4页
Military Medical Journal of South China
基金
湖北省卫生健康委科研联合项目(WJ2019H092)
关键词
新型冠状病毒肺炎
临床分型
临床特征
实验室检查指标
Coronavirus disease 2019
Clinical classification
Clinical features
Laboratory indicators
作者简介
通信作者:刘磊,E-mail:liulei890207@163.com
