摘要
目的 探讨儿童癫患者认知功能状况和P3 0 0 特点及二者关系。方法 对 38例儿童癫采用odd ball刺激序列检测P3 0 0 ,采用中国修订韦氏儿童智力量表 (WISC -RC)测定智商。结果 1.癫儿童智商低于正常 6 5 .8% ,智力损害 2 8.9% ;2 .P3 0 0 潜伏期和波幅较对照组明显延长和降低 (P <0 .0 1) ,且智力正常的癫组P3 0 0 潜伏期和波幅较对照组也明显延长和降低 (P <0 .0 5 ) ;3.相关分析显示P3 0 0 潜伏期与各智商间均呈显著负相关 (r =- 0 .2 76～ - 0 .32 7 P均 <0 .0 5 ) ,波幅与语言智商、总智商呈显著正相关。结论 癫儿童存在不同程度的认知障碍 ,智商和P3 0 0 有密切关系 ,但二者又不完全等同 。
Objective To explore the cognitive function,feature of P 300 event-related potentials and the relationship of them in children with epilepsy.Methods Auditory P 300 was measured by oddball paradigm and intelligence quotient was tested by WSIC-RC in 38 children with epilepsy.Results 1. The rates of FIQ less than normal IQ were 65.8 %, impaired intelligence 28.9 % in patient group. 2.The latencies and the amplitudes of P 300 were significantly delayed and decreased respectively in both patient groups (P<0.01) and FIQ with normal IQ (P<0.05), compared with those in normal control group. 3. There were significant negative bettween P 300 latency and VIQ,PIQ,FIQ respectively (r=-0.273--0.327,P<0.05). There was significant positive correlation between P 300 amplitude and VIQ,FIQ respectively (P<0.05).Conclusions Some of children′s epileptic patients may have deficiency of the cognitive function. FIQ and P 300 have a close relationship but are entirely identical in psychological significance and sensitivity.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2004年第8期662-664,共3页
Journal of Applied Clinical Pediatrics
关键词
儿童
癫痫
认知功能
事件相关电位
P300
children
epilepsy
cognitive function
event-related potential
P 300
