摘要
目的：探讨脑脊液置换联合万古霉素与地塞米松鞘内注射对术后颅内感染生化指标的影响，以期提高临床诊治水平。方法选取武警北京总队第三医院2010年2月～2013年4月70例颅内感染患者为研究对象，分成2组。对照组（n=35）予脑脊液置换术和头孢曲松静脉滴注；观察组（n=35）予脑脊液置换联合万古霉素与地塞米松鞘内注射治疗。观察2组治疗后临床效果和生化指标情况。结果对照组痊愈率22.86%、总有效率77.14%，观察组痊愈率37.14%、总有效率91.43%，2者比较差异有统计学意义（P<0.05）。治疗后2组在白细胞、葡萄糖、蛋白定量、颅内压上差异也有统计学意义（P<0.05）。结论脑脊液置换联合万古霉素与地塞米松鞘内注射能提高颅内感染治疗疗效。
Objective To investigate the effect of cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal therapy on biochemical indicators of postoperative intracranial infection, in order to improve the clinical diagnosis and treatment. Methods 70 cases with intracranial infection collected in Third Hospital of Beijing Armed Police Corps from February 2010 to April 2013 were as subject, and randomly divided into two groups. Control group(n=35) were given cerebrospinal lfuid replacement and ceftriaxone intravenously, observation group(n=35) were given cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal injection. The clinical effects and biochemical indicators were observed after treatment in two groups. Results In control group, the cure rate was 22.86%and total efifciency was 77.14%. In observation group, the cure rate was 37.14% and total efficiency was 91.43%. The differences between two groups were statistically significant (P<0.05). The differences of leukocytes, glucose, protein, intracranial pressure in two groups after treatment were also statistically signiifcant(P<0.05). Conclusion Cerebrospinal lfuid replacement combined with vancomycin and dexamethasone intrathecal injection therapy can increase intracranial infection.
出处
《中国生化药物杂志》
CAS
北大核心
2014年第2期83-85,89,共3页
Chinese Journal of Biochemical Pharmaceutics
基金
北京市卫生局一般规划项目(BW-2010BNO.020)
关键词
脑脊液置换
鞘内注射
颅内感染
生化指标
cerebrospinal fluid replacement
intrathecal injection
intracranial infection
biochemical markers
