摘要
目的:回顾性统计分析本院临床药学对4种治疗药物血药浓度监测结果,为临床合理用药提供参考。方法:用荧光偏振免疫法(FPIA)测定血药浓度。结果:4种药物2000至2004年间进行血药浓度监测,1301例次抗癫痫药物监测中,达有效血药浓度的703例次,占总数54.1%;低于达有效血药浓度的515例次,占总数39.6%;高于有效血药浓度的83例次,占总数6.3%。310例次甲氨蝶呤监测中,未中毒共有258例次,占83.3%;中毒共有28例次,占9.1%。结论:血药浓度监测是指导临床用药的依据之一,提示临床加强治疗药物监测重要性和必要性的认识,实行个体化给药,保证患者用药安全、有效、发挥药物的最佳效应。
Objective:To in order to gave the rational advice for clinical therapy,the results of monitoring 4 drugs concentration in 1611 cases were analyzed in our hospital.Methods:The serm concentration of 4 drugs was determined by fiuorescence polarization immnoassay(FPIA).Results:1301 cases of anti-epilepsies were analyzed,703 points were located at therange of effective blood concentrations,accont for 54.1%;515 points were lower to the range of effective blood concentrations;83 points were higher to the range of effective blood concentrations.310 cases of MTX were analyzed,258 points were in theraputic window,accont for 83.3%;28 points were up to toxin blood concentrations,accont for 9.1%.Conclusion:Serum drugs concentration is the important to guide the rational administration.these suggested that the realization of the importance and necessity of TDX should be adequate,so that the individual administrating programs of certain drugs should be implemented to ensure the safety and efficacy of therapeutic.
出处
《航空航天医学杂志》
2009年第10期28-29,共2页
Journal of Aerospace medicine
