摘要
目的通过比较有氧运动前后2型糖尿患者与非糖尿患者血乳酸水平增高的程度,进一步证实2型糖尿患者存在氧化磷酸化受阻,并由此推导出胰岛素抵抗的起始原因(细胞内ATP/AMP增高)。方法选取2型糖尿患者及非糖尿患者各18例,随机分入糖尿病组及非糖尿病组,两者在年龄、性别、BMI方面基本匹配。有氧运动设计为15分钟的自行车踏车运动。运动前及运动过程的第5、10、15分钟分别测定血糖及血乳酸水平。结果 2型糖尿患者组血乳酸增高的绝对值及比例超过非糖尿患者组,具有显著统计学意义(P<0.01)。结论 2型糖尿患者存在氧化磷酸化能力的下降。因此,与非糖尿患者群比较,2型糖尿患者有氧运动时产生更多乳酸。
Objective Based on the abnormality of retarded oxidative phosphorylation or dysfunction of mitochondrion in patients with type 2 diabetes mellitus(T2DM),we hypothesized that anaerobic metabolism would be activated,more lactic acid would be generated in patients with T2DM and ATP would be in great demand.This study was aimed at pursuing the original cause of the metabolic syndrome(MS) by observing the changes of plasma lactate concentration in patients with T2DM during aerobic exercise.Methods 18 patients with T2DM and 18 non-diabetic volunteers were recruited and divided into 2 groups(diabetic group,non-diabetic group),both matching in age,gender,BMI.Aerobic exercise was designed as 15 minutes of bicycle ergometer exercise.At 5min,10min,15min before and during the exercise,the blood glucose and blood lactate level were measured.Results The absolute and percentage value of type 2 diabetes group blood lactate increased more than that of the non-diabetic group,with notable statistical significance(P<0.01).Conclusion The oxidative phosphorylation capacity of patients with type 2 diabetes mellitus reduces,therefore,compared with non diabetic population,people with type 2 diabetes aerobic yield more lactic acid during aerobic exercise.
出处
《健康教育与健康促进》
2012年第1期63-64,81,共3页
Health Education and Health Promotion
基金
上海市徐汇区医学科研课题项目(SHXH201033)
关键词
糖尿病
乳酸
有氧运动
代谢综合征
Diabetes mellitus
Lactic acid
Aerobic exercise
Metabolic syndrome
