摘要
目的:探讨疏风止咳汤治疗咳嗽性哮喘的作用机制。方法:参照 Huston 方法建立豚鼠哮喘模型,在成功造模的基础上,选择与气道变应性炎症有密切相关并具有抗气道炎症评价意义的多项指标,实验中检测了气道反应性,支气管肺泡灌洗液(BALF)中细胞总数、嗜酸粒细胞(EOS)绝对值计数、嗜酸性粒细胞阳离子蛋白(ECP)、白介素-4(IL-4)、白介素-5(IL-5)、干扰素-γ(IFN-γ)等的含量变化。结果:(1)疏风止咳汤能够阻断气道炎症的发生、发展过程而降低哮喘豚鼠气道高反应性。(2)疏风止咳汤能够促进 Th_1细胞分泌IFN-γ,抑制 Th_2细胞分泌 IL-4、IL-5等细胞因子,调节 Th_1/Th_2细胞之间的平衡。(3)疏风止咳汤能够降低BALF 中 IL-5水平,抑制 EOS 的分化和增殖及向气道的趋化及浸润;抑制嗜酸粒细胞的激活和减少 ECP 等炎性介质的释放,从而减轻气道变应性炎症。结论:疏风止咳汤治疗咳嗽性哮喘是通过多种途径、多个环节作用于影响疾病的多个靶点,发挥联合协同作用而完成的。
Objective:To observe the effect of Shufeng Zhike Decoction (SFZKD) in treating cough variant asthma and its mechanism. Methods:Huston method was used to establish a guinea pig asthma model.Many indexes were chosen which was closely related to airway allergic inflammation to test the airway responsiveness,including BALF cell total number,eosinophil absolute count and the quantity changes of eosinophil cationic protein (ECP),IL-4,IL-5 and IFN-γ,etc.Results:(1) SFZKD could arrest airway inflam- mation and its ...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2003年第S1期89-92,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
咳嗽性哮喘
气道炎症
气道高反应性
疏风止咳汤
cough variant asthma
airway allergic inflammation
airway hyper-responsiveness
Shufeng Zhike Decoction
