摘要
目的探讨血清降钙素原(PCT)在新生儿缺氧缺血性脑病(HIE)医院感染临测中的意义。方法采用半定量固相免疫色谱法,对38例发生医院感染的HIE新生儿(感染组)、30例未感染HIE新生儿(未感染组)的血清PCT进行测定,并与超敏C反应蛋白(hs-CRP)作比较。结果感染组中PCT阳性率(81．58%)与hs-CRP(73．68%)比较差异无显著意义(P＞0．05)；感染组PCT阳性率明显高于未感染组(6．67%,P＜0．01),而感染组hs-CRP阳性率与未感染组(60．00%)比较差异无显著性(P＞0．05)。结论血清PCT检测有助于新生儿HIE患儿继发感染的早期、快速诊断,可作为新生儿HIE患儿发生医院感染的重要监测指标。
Objective To study the significance of procalcitonin(PCT) in monitoring nosocomial infection among the neonates with hypoxic-ischemic encephalopathy(HIE).Methods Semi-quantitative solid-phase immune chromato- graphy was used to detect the serum PCT in 38 cases of neonatal HIE with nosocomial infection( infection group),and 30 cases of neonatal HIE without infection(non-infection group).In addition the serum high-sensitivity C reactive protein(hs-CRP) was assayed for comparative analysis.Results The positive rate of PCT in the infection group was 81.58%,which was significantly higher than that in the non-infection group(6.67%,P＜0.01).The positive rates of hs - CRP in infection group and non-infection group were 73.68% and 60.00% respectively,and there showed no significant difference between the two groups(P＞0.05).The difference between the positive rate of POT and that of hs- CRP was not significant in the infection group(P＞0.05).Conclusions Serum PCT can be helpful in the early recognition and quick diagnosis of nosocomial infec- tions in neonates with HIE.POT seems to be an important index to monitor the nosocomial infection in neonates with HIE.
出处
《实用预防医学》
CAS
2006年第6期1627-1628,共2页
Practical Preventive Medicine
关键词
缺氧缺血性脑病
医院感染
降钙素原
超敏C反应蛋白
新生儿
Hypoxic-ischemic encephalopathy
Nosocomial infection
Procalcitonin
High-sensitivity C reactive protein
Neonate
作者简介
黄彩芝(1976-),女,湖南沅江市人,本科学历,检验师,主要从事临床免疫学研究工作.
