摘要
光敏剂能够选择性被肿瘤组织吸收并潴留,经特定波长激光照射发出特征性荧光可用于肿瘤病灶的诊断。同时,光敏剂在特定波长激光照射下诱发光化学反应,产生细胞毒性,可以杀灭肿瘤细胞。腹腔镜下5-氨基酮戊酸光动力学疗法(5-aminolevulinic acid-photodynamic therapy,5-ALA-PDT)能提高复发性卵巢癌的阳性诊断率。动物实验研究表明,光动力学疗法已能成功地治疗卵巢癌腹腔广泛转移灶,明显延长患者的生存期。
Photosensitizers can be selectively absorbed by the tumor tissue and stay there.Being irradiated by the particular wave-length laser,photosensitizers can send out the characteristic fluorescence for the detection of carcinoma metastases.At the same time,photosensitizers irradiated by the particular wave-length laser can induct the photochemistry reaction,and the creation of cell toxicity can kill tumor cells.Laparoscopic photodynamic diagnosis of recurrent ovarian cancer using 5-aminolevulinic acid(5-ALA)can raise positive diagnosis rate.Animal experimental studies that photodynamic treatment of extensive epithelial ovarian carcinoma metastases have already been successful,and survival time is prolonged distinctively.
出处
《中国激光医学杂志》
CAS
CSCD
2006年第6期395-398,共4页
Chinese Journal of Laser Medicine & Surgery
关键词
腹腔镜
光动力学疗法
卵巢癌
Laparoscope
Photodynamic therapy
Ovarian cancer
作者简介
张文杰(1980～),女,湖南黄坡人,硕士研究生,主要从事妇科腹腔镜的临床应用和基础研究.
