摘要
目的观察光动力疗法(photodynamic therapy,PDT)治疗皮肤肿瘤的临床疗效及不良反应。方法对病理检查确诊的31例皮肤肿瘤患者(基底细胞癌14例,鳞状细胞癌11例,皮脂腺癌1例,汗腺癌1例,上皮样肉瘤1例,皮肤转移性腺癌3例),给予血啉甲醚5mg/kg静滴,24h、48h、72h后行632.8nm激光照射,能量密度(648.42±16.45)J/cm2。4周1个疗程,治疗3个疗程后评价疗效。结果31例患者中完全缓解率74.20%(23/31),部分缓解率12.90%(4/31),总有效率87.10%,无效率12.90%(4/31)。完全缓解患者随访19个月以上,1年后复发率26.09%(6/23),中位疾病进展时间13.2个月,再次给予光动力治疗后完全缓解。所有患者无严重不良反应。结论光动力疗法治疗皮肤肿瘤,安全有效,值得临床推广应用。
Objectivey To evaluate the clinical efficacy and adverse effects of photodynamic therapy(PDT) in patients with skin cancer.Methodsy Thirty-one patients with skin cancer were treated with PDT.Hematoporphyrin derivative was used as photosensitizer,which was given in a dose of 5mg/kg.A 632.8nm laser was performed on the patients 24,48 and 72h after intravenous injection of photosensitizer,and the dose density was(648.42±16.45)J/cm2.PDT was peformed every 4 weeks,and the efficacy was evaluated after 3 treatment periods by PDT.Resultsy Complete response rate was 74.20%(23/31),partial response rate was 12.90%(4/31).The overall response rate was 87.10%(27/31).After follow-up for over 19 months,the recurrence rate was 26.09%,the medium time to progression was 13.2 months.Those complete remission after treated with PDT again.No patients had severe adverse effects.Conclusiony PDT is an efficiency and safety therapy for skin cancer.
出处
《实用皮肤病学杂志》
2009年第3期160-162,共3页
Journal of Practical Dermatology
关键词
皮肤肿瘤
光动力疗法
Skin cancer
Photodynamic therapy
