摘要
目的了解贵州野生多汁乳菇对60Co-γ辐射损伤小鼠的保护作用。方法实验设3个多汁乳菇剂量组(2.3、4.5、9.0 g/kg体重)、阴性对照组和60Co-γ辐射模型对照组,辐射剂量为5 Gy。观察小鼠白细胞计数、测定骨髓DNA含量。结果辐照后5 d小鼠各剂量组的白细胞总数(6.83±1.95、6.42±1.00、6.34±1.23)明显高于60Co-γ辐射对照组(5.05±0.93)(P<0.01);辐照后4、15 d,多汁乳菇各剂量组小鼠随剂量增加,DNA损伤程度逐渐降低,呈剂量反应关系(P<0.05)。结论在本实验条件下,多汁乳菇对60Co-γ辐射导致的小鼠白细胞损伤、DNA损伤具有一定的保护作用。
Objective To observe the protective effect of wild lactarius volemus in Guizhou on mice radiated by 60Co-γ ray.Methods Mice were randomly divided into 5 groups: 3 test groups administered with lactarius volemus(2.3 g/kg BW,4.5 g/kg BW,9.0 g/kg BW respectively),negative control group,and positive control group.Mice were dealt with 5 Gy irradiation in test and positive groups.The indices including the numbers of peripheral blood leukocytes and the contents of bone marrow DNA were detected.Results The numbers of peripheral blood leukocytes in test groups were significantly more than that in positive control group on day 5 after irradiation(P<0.01),there were negative correlation between the dose of lactarius volemus and the level of DNA damage and had dose-effect relationship on day 4 and day 15 after irradiation(P<0.05).Conclusion The wild lactarius volemus protects the mice from the damage of leukocytes and DNA induced by 60Co-γ radiation.
出处
《中国卫生工程学》
CAS
2007年第3期129-130,共2页
Chinese Journal of Public Health Engineering
基金
贵州省卫生厅科研项目(黔卫发〔2004〕156号)
作者简介
刘佳(1964-),女,副主任技师,学士,研究方向:保健食品毒理学
