摘要
慢性便秘是老年人常见的消化系统疾病,便秘症状的反复和持续会严重影响老年人的生活质量,甚至诱发其他系统疾病。越来越多的证据表明,慢性便秘与肠道菌群紊乱存在密切关联,肠道菌群组成及多样性失衡将诱发或加剧慢性便秘症状。由于衰老和其他因素影响,老年人的肠道菌群往往具有独特特征。本文通过阐述老年慢性便秘患者的肠道菌群改变,从短链脂肪酸、结肠转运时间和脑肠轴等多方面探讨老年人便秘的发生机制,以及益生菌、益生元、合生元、非吸收性抗生素和粪菌移植等基于肠道菌群靶点的治疗方案,以期为老年慢性便秘患者的临床治疗提供理论依据和参考。
Chronic constipation is a common digestive disease among the elderly,and the recurrence and persistence of constipation symptoms can seriously affect the quality of life of the elderly and even induce other systemic diseases.Emerging evidence has highlighted a close relation between chronic constipation and intestinal flora disorders,and that an imbalance in the composition and diversity of intestinal flora will trigger or exacerbate chronic constipation symptoms.Due to aging and other factors,the intestinal flora of the elderly often has unique characteristics.This article discusses the changes of intestinal flora in elderly patients with chronic constipation,exploring the mechanisms of constipation in the elderly in terms of short-chain fatty acids,colonic transit time,and the brain-gut axis,as well as therapeutic options based on intestinal flora targets,such as probiotics,prebiotics,synbiotics,non-absorbable antibiotics,and fecal transplants,so as to provide theoretical basis and reference for the clinical treatment of elderly patients with chronic constipation.
作者
刘康蔚
姚健凤
Liu Kangwei;Yao Jianfeng(Department of Gastroenterology,Huadong Hospital Affliated to Fudan University,Shanghai 200040,China)
出处
《中华老年病研究电子杂志》
2023年第4期40-46,共7页
Chinese Journal of Geriatrics Research(Electronic Edition)
关键词
慢性便秘
肠道菌群
老年人
发病机制
治疗
Chronic constipation
Intestinal flora
Aged
Pathogenesis
Treatment
作者简介
通信作者:姚健凤,Email:yjf1966@126.com
