摘要
全球肥胖发病率逐年增长,与其密切相关的代谢性疾病非酒精性脂肪性肝病(NAFLD)发病率亦与日俱增,是慢性肝病的最常见病因之一,其机制可能与胰岛素抵抗、脂代谢紊乱、氧化应激、菌群失调和细胞自噬等有关。目前NAFLD确诊依赖肝活检,相对无创方便的血清学及影像学诊断方法也愈发成熟。研究表明减重可改善NAFLD肝脏组织学特征以及血脂等生化指标,目前减重的基本方法是干预改变生活方式,针对减重研发的药物也越来越丰富。同时,减重代谢手术对NAFLD获益确切,NAFLD或可成为减重代谢手术适应证之一。
The global incidence of obesity increases year by year,and the incidence of nonalcoholic fatty liver disease(NAFLD),a metabolic disease closely related to obesity,is also increasing day by day.NAFLD is one of the most common causes of chronic liver disease.Its mechanism may be related to insulin resistance,lipid metabolism disorder,oxidative stress,flora disorder and autophagy and so on.Diagnosis for NAFLD is currently dependent on liver biopsy,but relatively non-invasive and convenient serological and imaging diagnostic methods are also being more sophisticated.Studies have shown that weight loss can improve liver histological features and biochemical indicators such as blood lipids in NAFLD.At present,the basic method of weight loss is to change lifestyle,but drugs developed for weight loss are becoming increasingly diverse.At the same time,weight loss metabolic surgery has definite benefits for NAFLD,which may be one of the new indications for weight loss metabolic surgery in the future.
作者
陆远欣
龚莉琳
曾梦华
Lu Yuanxin;Gong Lilin;Zeng Menghua(The First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China)
出处
《中华肥胖与代谢病电子杂志》
2024年第2期113-119,共7页
Chinese Journal Of Obesity and Metabolic Diseases：Electronic Edition
基金
国家自然科学基金青年科学基金项目(81800757)
重庆市自然科学基金面上项目资助(cstc2021jcyj-msxmX0173)
关键词
肥胖
非酒精性脂肪肝病
发病机制
分型
治疗
减重代谢手术
Obesity
Non-alcoholic fatty liver disease
Pathogenesis
Classification
Treatment
Metabolic bariatric surgery
作者简介
通信作者:曾梦华,Email:tjzmh@foxmail.com,副主任医师,副教授,硕士研究生导师,重庆医科大学附属第一医院胃肠外科金山病区负责人。中国医疗保健国际交流促进会减重代谢外科委员,中国人体健康科技促进会肥胖糖尿病主动健康专业委员会委员,重庆医院管理协会外科管理专业委员会委员兼秘书,重庆市医学会微创外科分会胃肠外科学组委员兼秘书,重庆抗癌协会胃癌专业委员会委员,重庆市中西医结合协会睡眠医学专业委员会委员,重医一院普外专培基地秘书。主持完成国家自然科学基金一项,承担重庆市自然科学基金及市教委课题各一项,发表学术论文20余篇,其中第一作者或通讯作者发表SCI论文6篇,参编大型论著《移植学》及人卫整合医学教材《消化系统疾病》,参译《移植外科手术图谱》;通信作者:龚莉琳,Email:173183841@qq.com
