摘要
反复种植失败(RIF)是一个具有挑战性的临床难题。尽管近年来体外受精-胚胎移植技术飞速发展,RIF仍是影响女性成功妊娠的重要问题,至今难以形成统一的诊疗标准。RIF病因复杂,包括母体因素、男性因素和胚胎因素,其中母体因素又包括免疫异常、血栓前状态、子宫内膜容受性不良、感染、生殖系统解剖结构异常和内分泌稳态失衡等。RIF病因的复杂性和多样性决定了在临床工作中需针对不同病因制订个性化诊疗方案。本共识将为RIF的检查、评估和管理提供建议,为医生的决策提供参考,规范RIF诊治。
Recurrent implantation failure(RIF)is a challenging clinical problem.Although in vitro fertilization-embryo transfer technology has made remarkable advances,RIF remains a significant obstacle to achieving a successful pregnancy.A unified criterion of diagnosis and treatment for RIF has yet to be created.The etiology of RIF is complicated,including maternal,male,and embryonic factors.Maternal factors include dysimmunity,prethrombotic state,poor endometrial receptivity,infection,anatomical abnormalities,and endocrine disorders.The complexity and diversity of etiologies of RIF require clinicians to individualize the strategy of diagnosis and treatment for RIF patients.This consensus will provide the most relevant evidence to date for the examination,evaluation,and management of RIF,provide a reference for clinicians to make decisions,and standardize the diagnosis and treatment of RIF.
作者
中国医师协会生殖医学专业委员会
中国女医师协会生殖医学专业委员会
李蓉
石玉华
李达
Chinese Association of Reproductive Medicine;Professional Committee of Reproductive Medicine,China Medical Women′s Association;Li Rong;Shi Yuhua;Li Da(不详;Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China;Center for Reproductive Medicine,Guangdong Provincial People′s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Center for Reproductive Medicine,Shengjing Hospital of China Medical University,NHC Key Laboratory of Reproductive and Genetic Medicine,Shenyang 110022,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第2期89-100,共12页
National Medical Journal of China
关键词
生殖技术
胚胎移植
反复种植失败
免疫
血栓前状态
子宫内膜容受性
共识
Reproductive techniques
Embryo transfer
Recurrent implantation failure
Immunology
Prethrombotic state
Endometrial receptivity
Consensus
作者简介
通信作者:李蓉,北京大学第三医院妇产科生殖医学中心,北京100191,Email:roseli001@sina.com;通信作者:石玉华,广东省人民医院生殖医学中心广东省医学科学院,广州510080,Email:shiyuhua2003@126.com;通信作者:李达,中国医科大学附属盛京医院生殖医学中心国家卫生健康委员会生殖健康与遗传医学重点实验室,沈阳110022,Email:leeda@sina.cn
