摘要
阿尔茨海默病(AD)是老年期最常见的痴呆类型。患病率高,就诊率、诊断率及治疗率低是长期以来我国AD临床诊疗所面临的严峻挑战。脑内β-淀粉样蛋白沉积是AD连续疾病谱中最早发生的病理过程,先于认知下降等临床症状。规范AD诊疗过程中淀粉样蛋白正电子发射断层显像(PET)的操作和结果判读,实现显像流程及结果的可靠性、可重复性及可比性,将有助于疾病的早期精准诊断、疗效评估、转归预测。推荐对淀粉样蛋白PET图像进行全局二元解读(阳性、阴性)。在临床解读时淀粉样蛋白PET图像结果均应结合临床和神经心理学特征、其他形态和(或)功能性影像资料及其他的生物学标志物。
Alzheimer′s disease(AD)is known as the most prevalent type of dementia in the elderly population.However,AD is regarded as a persistent sever clinical challenge due to its high morbidity but low rates of diagnosis and treatment in China.Intracerebralβ-Amyloid protein deposition is the earliest pathological process that occurs in the continuous spectrum of AD,prior to clinical symptoms such as cognitive decline.Standardizing the operation and result interpretation of amyloid positron emission tomography(PET)during the clinical practice,and achieving the reliability,repeatability and comparability of the imaging process and results will contribute to the early and accurate diagnosis,efficacy evaluation,and outcome prediction.A global binary interpretation(positive or negative)of amyloid PET images is recommended.In clinical interpretation,amyloid PET image results should be combined with clinical and neuropsychological characteristics,other morphological and/or functional imaging data,and other biological markers.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2023年第45期3615-3626,共12页
National Medical Journal of China
基金
科技创新2030-重大项目(2022ZD0211603)
作者简介
通信作者:陈晓春,福建医科大学附属协和医院神经内科,福州350001,Email:chenxc998@fjmu.edu.cn;通信作者:李思进,山西医科大学第一医院核医学科,太原030001,Email:lisjnm123@vip.163.com
