摘要
Objective:To detect the expression levels of Forkhead box M1 (FoxM1) and Adisintegrin and metalloproteinase (ADAM17) proteins in colon cancer tissues and to analyze their relationship with clinical pathology of colon cancer.And to explore its clinical significance. Methods: From June 2016 to December 2017, 68 cases of colon cancer specimens and normal tissues adjacent to the colon cancer were obtained from the Department of General Surgery, North China University of Technology, and the pathologically confirmed colon cancer specimens were examined by immunohistochemistry. The positive expression rates of FoxM1 and ADAM17 proteins in the two groups were detected by immunohistochemistry, and the relationship between them and the clinicopathological features of colon cancer and their correlation were analyzed.Results: Compared with normal colon tissue, the positive rates of FoxM1 and ADAM17 protein expression in colon cancer tissues were significantly increased (P<0.05). The positive expression rate of FoxM1 and ADAM17 protein was correlated with tumor diameter, lymphatic metastasis and clinical stage (P<0.05), and had no correlation with age, gender, tumor differentiation degree and tumor invasion depth (P>0.05). The results of rank correlation analysis showed that there was a positive correlation between the expression of FoxM1 and ADAM17 protein in colon cancer tissues (rs=0.520,P<0.05).Conclusion: The positive expression rate of FoxM1 and ADAM17 protein in colon cancer tissues was higher than that in normal colon tissues. The positive expression of FoxM1 and ADAM17 was related to colon cancer diameter, lymphatic metastasis and clinical stage, suggesting that it may be related to poor prognosis of colon cancer.
作者简介
Corresponding author:Guo-Zhi Zhang,Department of General Surgery,Affiliated Hospital of North China University of Technology,Tangshan,Hebei,063000,China.
