摘要
目的:分析质子泵抑制剂在临床应用中的药学情况,旨在为临床合理用药提供参考依据.方法:随机抽选本院2018年1月—2018年12月开具的1200张质子泵抑制剂处方,运用回顾性调查分析法对质子泵抑制剂进行分类,做好详细记录,同时应用Excel表统计与分析处方数据,了解该类药物应用科室、销售金额、用药频度、日均药品费用以及不合理使用情况.结果:1200张质子泵抑制剂处方的应用科室包括血液科、呼吸科、消化内科、骨科、妇科、泌尿外科、普外科、心胸外科、神经外科;质子泵抑制剂的销售总金额为1030.43万元,排名前三依次为泮托拉唑注射剂、奥美拉唑注射剂、艾普拉唑肠溶片;质子泵抑制剂的总用药频度为287999,排名前三依次为兰索拉唑片、泮托拉唑注射剂、雷贝拉唑片/胶囊;质子泵抑制剂的日均药品总费用为473.57元,排名前三依次为兰索拉唑注射剂、埃索美拉唑注射剂、奥美拉唑注射剂;发现临床不合理用药处方49张,构成比为4.08%;不合理用药原因包括用法用量不合理27张(2.25%)、重复给药8张(0.67%)、药品配伍不合理7张(0.58%)、用药禁忌证5张(0.42%)、诊断与用药不相符2张(0.17%).结论:质子泵抑制剂在临床治疗中的应用广泛,分析其药学情况,有助于促进临床用药的合理性与安全性,对提高临床疗效具有重要的指导意义.
Objective:To analyze the pharmaceutical situation of proton pump inhibitors in clinical applications in order to provide a reference for clinically rational drug use.Methods:1 200 prescriptions of proton pump inhibitors issued by our hospital from January 2018 to December 2018 were randomly selected.The proton pump inhibitors were classified by a retrospective investigation analysis method,and detailed records were made.At the same time,Excel tables were used to statistically analyze the data of the prescriptions to understand the application departments,sales amount,use frequency,daily average cost and unreasonable use of the drugs.Results:The application departments of 1 200 proton pump inhibitor prescriptions include hematology department,respiratory department,gastroenterology department,orthopedics department,gynecology department,urology department,general surgery department,cardiothoracic surgery department and neurosurgery department.The total sales amount of proton pump inhibitors is 10.034 3 million yuan,and the top three prescriptions are pantoprazole injection,omeprazole injection and ilaprazole enteric-coated tablets.The total frequency of proton pump inhibitors is 287,999,and the top three prescriptions are lansoprazole tablets,pantoprazole injection and rabeprazole tablets/capsules.The average daily cost of proton pump inhibitors is 473.57 yuan,and the top three prescriptions are lansoprazole injection,esomeprazole injection and omeprazole injection.49 unreasonable prescriptions were found in clinic,with a constitutive ratio of 4.08%.The causes for irrational drug use include unreasonable dosage of 27 prescriptions(2.25%),repeated administration of 8 prescriptions(0.67%),unreasonable drug compatibility of 7 prescriptions(0.58%),drug contraindications of 5 prescriptions(0.42%)and inconsistent diagnosis of 2 prescriptions(0.17%).Conclusion:Proton pump inhibitors are widely used in clinical treatment.Analysis of their pharmaceutical situation can help to promote the rationality and safety of clinical drug use,and has important guiding significance for improving clinical efficacy.
作者
郜娜
Gao Na(Department of Pharmacy,Cancer Hospital Affiliated to Zhengzhou University,Zhengzhou Henan 450008,China)
出处
《中国合理用药探索》
CAS
2019年第6期183-185,189,共4页
Chinese Journal of Rational Drug Use
关键词
质子泵抑制剂
临床应用
药学分析
销售金额、用药频度、日均药品费用
Proton Pump Inhibitor
Clinical Application
Pharmaceutical Analysis
Sales Amount,Frequency of Drug Use
Daily Average Drug Cost
作者简介
郜娜,女,主管药师。研究方向:医院药学方面。E-mail:gaona6677@126.com
