摘要
目的研究奥扎格雷钠对急性脑梗死患者血液流变学及血清肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平的影响.方法选取本院2019年1月—2021年1月收治的急性脑梗死患者122例,按照随机数表法分为对照组和观察组,每组61例.对照组采用阿司匹林及甘露醇等常规药物治疗,观察组在对照组基础上采用奥扎格雷钠治疗,两组患者均治疗15 d.比较两组的临床效果及治疗前后的血液流变学、血清炎性因子水平.结果观察组的治疗总有效率为98.36%,高于对照组的80.32%,差异有统计学意义(P<0.05).两组治疗后的血清CRP、IL-6、TNF-α水平,全血高切黏度、全血低切黏度、全血还原黏度、红细胞比容均较治疗前明显降低,且观察组各项指标水平均明显低于对照组,差异有统计学意义(P<0.05).结论奥扎格雷钠可降低急性脑梗死患者的炎性因子水平,改善血液流变学指标,与常规药物联用的治疗效果显著.
Objective To study the effects of ozagrel sodium on hemorheology,serum levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and interleukin-6(IL-6)in patients with acute cerebral infarction.Methods A total of 122 patients with acute cerebral infarction admitted to our hospital from January 2019 to January 2021 were selected and were divided into a control group and an observation group according to random number table method,with 61 cases in each group.The control group was treated with conventional drugs such as aspirin and mannitol,and the observation group was treated with Ozagrel sodium on the basis of the control group.Both groups were treated for 15 d.The clinical effect and the levels of hemorheology and serum inflammatory factors before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 98.36%,higher than 80.32%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of serum CRP,IL-6,TNF-α,whole blood high tangential viscosity,whole blood low tangential viscosity,whole blood reducing viscosity and RBC specific volume in the two groups were significantly lower than those before treatment,and the indexes above in the observation group were significantly lower than those in control group,the differences were statistically significant(P<0.05).Conclusion Ozagrel sodium can reduce the levels of inflammatory factors in patients with acute cerebral infarction and improve the hemorheology indexes,the treatment effect is remarkable combined with conventional drug.
作者
林世泳
LIN Shiyong(Department of Neurology,Xuwen People's Hospital of Guangdong Province,Zhanjiang Guangdong,524100,China)
出处
《反射疗法与康复医学》
2021年第19期39-41,共3页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
奥扎格雷钠
血液流变学
血清炎性因子
Acute cerebral infarction
Ozagrel sodium
Hemorheology
Serum inflammatory factors
作者简介
林世泳(1976-),男,广东徐闻人,本科,副主任医师,研究方向:脑梗死康复治疗。
