摘要
目的探究急性脑梗死患者采用丁苯酞氯化钠注射液与依达拉奉注射液联合治疗对其神经功能缺损程度及生活质量的影响.方法选择2020年3月—2021年6月于本院接受治疗的88例急性脑梗死患者为此次研究对象,按照随机数字表法分为对照组44例和观察组44例.对照组采用依达拉奉注射液治疗,观察组在对照组基础上加用丁苯酞氯化钠注射液治疗,两组均持续治疗2周.比较两组治疗效果、治疗前后神经功能缺损程度、生活质量以及不良反应.结果观察组治疗总有效率为95.45%,高于对照组的79.55%,差异有统计学意义(P<0.05).治疗后,观察组美国国立卫生研究院卒中量表评分(8.60±1.58)分低于对照组,生活质量综合评定问卷中躯体功能评分(62.47±6.58)分、心理功能评分(72.31±6.20)分、社会功能评分(76.42±6.38)分及物质生活状态评分(70.15±6.28)分均高于对照组,组间差异有统计学意义(P<0.05).观察组的不良反应发生率13.64%与对照组的9.10%比较,差异无统计学意义(P>0.05).结论临床在急性脑梗死患者中联合采用丁苯酞氯化钠注射液与依达拉奉注射液治疗的疗效确切,能够减轻患者的神经功能缺损程度,促进其生活质量改善,且不良反应少.
Objective To explore the effect of combined treatment with butylphthalide sodium chloride injection and edaravone injection on the degree of neurological deficit and quality of life in patients with acute cerebral infarction.Methods A total of 88 patients with acute cerebral infarction who were treated in our hospital from March 2020 to June 2021 were selected as the research subjects,and were divided into a control group with 44 cases and an observation group with 44 cases according to the random number table method.The control group was treated with edaravone injection,and the observation group was additionally treated with butylphthalide sodium chloride injection on the basis of the control group.Both groups were treated for 2 weeks.The treatment effect,degree of neurological deficit,quality of life before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.45%,which was higher than 79.55%in the control group,and the difference was statistically significant(P<0.05).After treatment,the National Institute of Health stroke scale score(8.60±1.58)points in the observation group was lower than that in the control group,the physical function score(62.47±6.58)points,the psychological function score(72.31±6.20)points,the social function score(76.42±6.38)points and the material living state score(70.15±6.28)points in the generic quality of life inventory-74 were all higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 13.64%,compared with 9.10%in the control group,the difference was not statistically significant(P>0.05).Conclusion Clinically,the combined use of butylphthalide sodium chloride injection and edaravone injection in patients with acute cerebral infarction has definite curative effect,can reduce the degree of neurological deficit of patients,promote the improvement of their quality of life,and has few adverse reactions.
作者
崔艳
CUI Yan(Department of Pharmacy,Harbin First Hospital,Harbin Heilongjiang,150010,China)
出处
《反射疗法与康复医学》
2021年第21期50-52,71,共4页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
丁苯酞氯化钠注射液
依达拉奉注射液
神经功能
生活质量
疗效
Acute cerebral infarction
Butylphthalide sodium chloride injection
Edaravone injection
Neurological function
Quality of life
Efficacy
作者简介
崔艳(1982-),女,山东平度人,硕士研究生,主管药师,研究方向:临床药学。
