摘要
目的探讨鼻内镜手术联合布地奈德治疗慢性鼻-鼻窦炎伴鼻息肉(CRSwNP)的临床效果.方法选取2018年1月—2020年12月我院收治的50例CRSwNP患者为研究对象,按随机数字表法分为两组,各25例.对照组采用鼻内镜手术治疗,观察组在对照组基础上术后加用布地奈德治疗,均随访至术后3个月.比较两组临床症状积分、嗅觉功能以及炎症因子水平.结果观察组术后3个月鼻塞积分、头痛积分、流涕积分及嗅觉减退积分分别为(0.76±0.14)分、(0.59±0.11)分、(0.68±0.12)分、(0.55±0.11)分,均低于对照组,组间差异有统计学意义(P<0.05).观察组术后3个月气味识别能力评分、气味辨别能力评分、气味感觉阈值评分及总分分别为(13.54±1.71)分、(13.87±1.68)分、(13.75±1.64)分、(41.16±4.08)分,均高于对照组,组间差异有统计学意义(P<0.05).观察组术后3个月肿瘤坏死因子-α、白细胞介素-6水平分别为(115.41±8.96)pg/mL、(13.52±2.14)pg/mL,均低于对照组,组间差异有统计学意义(P<0.05).结论鼻内镜手术联合布地奈德可加快CRSwNP患者的鼻腔炎症消退,降低临床症状积分,促进嗅觉功能恢复.
Objective To investigate the clinical effect of endoscopic sinus surgery combined with budesonide in the treatment of chronic rhinosinusitis with nasal polyps(CRSwNP).Methods 50 patients with CRSwNP admitted to the hospital from January 2018 to December 2020 were selected as the research objects,and divided into two groups according to the random number table method,with 25 cases in each group.The control group was treated with endoscopic sinus surgery,and the observation group was additionally treated with budesonide after surgery on the basis of the control group.Both groups were followed up to 3 months after surgery.The clinical symptom scores,olfactory function and the levels of inflammatory factors were compared between the two groups.Results 3 months after operation,the scores of nasal congestion,headache,runny nose and hyposmia in the observation group were(0.76±0.14)points,(0.59±0.11)points,(0.68±0.12)points,and(0.55±0.11)points,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).3 months after operation,the odor recognition ability score,odor recognition ability score,odor perception threshold score and total score of the observation group were(13.54±1.71)points,(13.87±1.68)points,(13.75±1.64)points,(41.16±4.08)points,respectively,which were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).3 months after operation,the levels of tumor necrosis factor-αand interleukin-6 in the observation group were(115.41±8.96)pg/mL,(13.52±2.14)pg/mL,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Endoscopic sinus surgery combined with budesonide can accelerate the resolution of inflammation of the nasal cavity in patients with CRSwNP,reduce clinical symptom scores,and promote the recovery of olfactory function.
作者
包雪梅
BAO Xuemei(Department of Otolaryngology,International Mongolian Medical Hospital of Inner Mongolia Autonomous Region,Hohhot Inner Mongolia,010065,China)
出处
《反射疗法与康复医学》
2022年第7期139-142,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性鼻-鼻窦炎
鼻息肉
鼻内镜手术
布地奈德
嗅觉功能
Chronic rhinosinusitis
Nasal polyps
Endoscopic sinus surgery
Budesonide
Olfactory function
作者简介
包雪梅(1984-),女,蒙族,内蒙古通辽人,硕士研究生,副主任医师,研究方向:耳鼻喉科临床。
