摘要
目的探讨背根神经节脉冲射频消融联合臭氧皮内注射在带状疱疹后遗神经痛(PHN)患者中的临床应用效果.方法选取我院2020年6月—2022年6月收治的84例PHN患者为研究对象,按随机数字表法分为两组,各42例.对照组采用背根神经节脉冲射频消融治疗,观察组在对照组基础上加用臭氧皮内注射治疗,均治疗4周.比较两组临床疗效、疼痛程度、睡眠质量、炎症指标水平、致痛因子水平以及不良反应.结果观察组总有效率较对照组高,治疗后疼痛视觉模拟评分、匹兹堡睡眠质量指数量表评分分别为(1.53±0.32)分、(6.82±1.24)分,均低于对照组的(2.72±0.39)分、(8.65±1.33)分,组间差异有统计学意义(P<0.05).观察组治疗后C反应蛋白、红细胞沉降率、白细胞介素-6水平分别为(4.85±0.86)mg/L、(15.86±2.13)mm/h、(8.96±1.05)ng/L,均低于对照组的(5.71±1.13)mg/L、(18.74±2.25)mm/h、(11.32±1.29)ng/L,组间差异有统计学意义(P<0.05).观察组治疗后前列腺素E2、单核细胞趋化蛋白-1水平分别为(125.35±10.42)ng/L、(56.36±5.71)ng/L,均低于对照组的(158.96±14.36)ng/L、(61.41±6.15)ng/L,组间差异有统计学意义(P<0.05).两组不良反应发生率相比,差异无统计学意义(P>0.05).结论背根神经节脉冲射频消融联合臭氧皮内注射可提高PHN的治疗效果,减轻炎症反应,减少致痛因子释放,降低疼痛程度,改善睡眠质量,且安全可靠.
Objective To investigate the clinical application effect of pulsed radiofrequency ablation of dorsal root ganglion combined with intradermal ozone injection in patients with postherpetic neuralgia(PHN).Methods 84 PHN patients admitted to the hospital from June 2020 to June 2022 were selected as the research objects and divided into two groups according to the random number table,42 patients in each group.The control group was treated with pulsed radiofrequency ablation of the dorsal root ganglion,and the observation group was treated with intradermal ozone injection on the basis of the control group.Both groups were treated for 4 weeks.The clinical efficacy,pain severity,sleep quality,inflammation indicators level,pain causing factor level and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was higher than that of the control group,after treatment,the pain visual analogue scale scores and Pittsburgh sleep quality index scores were(1.53±0.32)points and(6.82±1.24)points,respectively,which were lower than(2.72±0.39)points and(8.65±1.33)points of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of C-reactive protein,erythrocyte sedimentation rate and interleukin-6 in the observation group were(4.85±0.86)mg/L,(15.86±2.13)mm/h and(8.96±1.05)ng/L,respectively,which were lower than(5.71±1.13)mg/L,(18.74±2.25)mm/h and(11.32±1.29)ng/L in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the prostaglandin E2 and monocyte chemotactic protein-1 in the observation group were(125.35±10.42)ng/L and(56.36±5.71)ng/L,respectively,which were lower than(158.96±14.36)ng/L and(61.41±6.15)ng/L in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pulsed radiofrequency ablation of dorsal root ganglion combined with intracutaneous ozone injection can improve the therapeutic effect of PHN,reduce inflammatory reaction,reduce pain factor release,reduce the severity of pain,and improve sleep quality,which is safe and reliable.
作者
杩铁磬
李永
MA Tieqing;LI Yong(Department of Orthopedic Pain,Beijing Jiangong Hospital,Beijing,075000,China)
出处
《反射疗法与康复医学》
2022年第23期120-123,共4页
Reflexology And Rehabilitation Medicine
关键词
带状疱疹后遗神经痛
背根神经节脉冲射频消融
臭氧
皮内注射
疼痛
Postherpetic neuralgia
Pulsed radiofrequency ablation of dorsal root ganglion
Ozone
Intradermal injection
Pain
作者简介
杩铁磬(1982-),男,河北沧州人,本科,主治医师,研究方向:骨伤科疼痛治疗。
