摘要
目的探究多囊卵巢综合征(PCOS)不孕患者应用来曲唑促排卵治疗的临床效果.方法选择我院2020年1月—2021年11月收治的66例PCOS不孕患者,按照随机数字表法将其分为两组.对照组(n=33)采用氯米芬促排卵治疗,研究组(n=33)采用来曲唑促排卵治疗.比较两组内分泌指标水平、子宫内膜情况、促排卵效果、排卵率、妊娠率、不良妊娠结局、不良反应和并发症发生情况.结果用药5d后,研究组睾酮、黄体生成素、促卵泡激素水平均高于对照组,组间差异有统计学意义(P<0.05).人绒毛膜促性腺激素注射当日,研究组子宫内膜厚度厚于对照组,宫腔容积大于对照组,成熟卵泡直径短于对照组,成熟卵泡数量少于对照组,组间差异有统计学意义(P<0.05).治疗后随访10个月,研究组排卵率、妊娠率均高于对照组,不良妊娠结局发生率低于对照组,组间差异有统计学意义(P<0.05).两组卵泡成熟时间、不良反应发生率、卵巢过度刺激综合征和未破裂卵泡黄素化综合征发生率比较,组间差异无统计学意义(P>0.05).结论来曲唑促排卵治疗PCOS不孕,可有效改善患者性激素水平,有利于促进排卵,提升妊娠率,改善妊娠结局,且用药安全可靠,值得临床推广应用.
Objective To explore the clinical effect of letrozole for ovulation induction in infertility patients with polycystic ovarian syndrome(PCOS).Methods 66 patients with PCOS infertility admitted to the hospital from January 2020 to November 2021 were selected and divided into two groups according to random number table method.The control group(n=33)received clomiphene ovulation induction therapy,and the study group(n=33)received letrozole ovulation induction therapy.The levels of endocrine indexes,endometrial conditions,ovulation promoting effect,ovulation rate,pregnancy rate,adverse pregnancy outcomes,adverse reactions and complications were compared between the two groups.Results After 5 days of administration,the levels of testosterone,luteinizing hormone and follicle-stimulating hormone in the study group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).On the day of chorionic gonadotropin injection,the endometrial thickness of the study group was thicker than that of the control group,the uterine volume was larger than that of the control group,and the diameter of mature follicles was shorter than that of the control group,the number of mature follicles in the study group was less than that in the control group,and the differences between the groups were statistically significant(P<0.05).10 moths of follow-up after treatment,the ovulation rate and pregnancy rate of the study group were higher than those of the control group,and the incidence of adverse pregnancy outcome was lower than that of the control group,and the differences between the groups were statistically significant(P<0.05).The follicle maturation time,incidence of adverse reactions,incidence of ovarian hyperstimulation syndrome and unruptured follicle luteinization syndrome were compared between the two groups,and the differences between the groups were not statistically significant(P>0.05).Conclusion In the treatment of PCOS infertility,letrozole for ovalation incluction can effectively improve patients'sex hormone levels,promote ovulation,increase pregnancy rate,and improve pregnancy outcome,and the drug is safe and reliable,worthy of clinical application.
作者
周爱武
温开群
陈珠
ZHOU Aiwu;WEN Kaiqun;CHEN Zhu(Department of Pharmacy,Yancheng Maternal and Child Health Hospital of Jiangsu Province,Yancheng Jiangsu,224001,China;Department of Reproductive Health,Yancheng Maternal and Child Health Hospital of Jiangsu Province,Yancheng Jiangsu,224001,China)
出处
《反射疗法与康复医学》
2023年第3期98-101,共4页
Reflexology And Rehabilitation Medicine
关键词
多囊卵巢综合征
来曲唑
促排卵
内分泌
妊娠结局
Polycystic ovarian syndrome
Letrozole
Ovulation induction
Endocrine
Pregnancy outcome
作者简介
周爱武(1969-),女,江苏盐城人,本科,主管药师,研究方向:临床药学、医院药事管理;通信作者:陈珠(1983-),女,江苏盐城人,本科,主管药师,研究方向:药学,邮箱:109015462@qq.com。
