摘要
目的探究鼓室内注射盐酸氨溴索及地塞米松治疗分泌性中耳炎(SOM)的效果。方法选取2021年1月—2022年11月枣庄市立医院收治的82例SOM患者为研究对象,按随机数字表法分为两组。对照组(n=41)采用鼓室内注射地塞米松治疗,观察组(n=41)采用鼓室内注射盐酸氨溴索及地塞米松治疗。比较两组患者的临床疗效、语频气导听阈、鼓室压、中耳积液炎症因子水平及不良反应发生情况。结果观察组的治疗总有效率为92.68%,高于对照组的73.17%,差异有统计学意义(P<0.05)。治疗后,观察组的语频气导听阈为(27.03±5.12)dB,低于对照组,鼓室压为(-86.08±8.64)daPa,高于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的肿瘤坏死因子-α、白细胞介素-5、降钙素原水平分别为(1.25±0.11)ng/mL、(2.21±0.13)pg/mL、(2.12±0.17)μg/L,均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用鼓室内注射盐酸氨溴索与地塞米松治疗SOM的效果显著,可促进患者听力恢复,减轻中耳炎症反应,安全性高,值得临床推广使用。
Objective To investigate the effect of intratympanic injection of ambroxol hydrochloride and dexamethasone in the treatment of secretory otitis media(SOM).Methods 82 SOM patients admitted to Zaozhuang Municipal Hospital from January 2021 to November 2022 were selected as the research objects and were divided into two groups according to random number table method.The control group(n=41)was treated with intratympanic injection of dexamethasone,and the observation group(n=41)was treated with intratympanic injection of ambroxol hydrochloride and dexamethasone.The clinical efficacy,speech frequency air conduction hearing threshold,tympanic pressure,middle ear effusion inflammatory factor levels and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 92.68%,higher than 73.17%of the control group,and the difference was statistically significant(P<0.05).After treatment,the speech frequency air conduction hearing threshold of the observation group was(27.03±5.12)dB,lower than that of the control group,and the tympanic pressure was(-86.08±8.64)daPa,higher than that of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factoralpha,interleukin-5 and procalcitonin in the observation group were(1.25±0.11)ng/mL,(2.21±0.13)pg/mL and(2.12±0.17)μg/L,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Intratympanical injection of ambroxol hydrochloride and dexamethasone in the treatment of SOM is effective,can promote the hearing recovery of patients,reduce the inflammation of the middle ear,and is safe,worthy of clinical promotion.
作者
陈琪
CHEN Qi(Department of Otolaryngology,Zaozhuang Municipal Hospital,Zaozhuang Shandong,277000,China)
出处
《反射疗法与康复医学》
2023年第9期100-102,106,共4页
Reflexology And Rehabilitation Medicine
关键词
分泌性中耳炎
盐酸氨溴索
地塞米松
语频气导听阀
鼓室压
Secretory otitis media
Intratympanic injection
Ambroxol hydrochloride
Dexamethasone
Tympanic pressure
作者简介
陈琪(1986-),女,山东枣庄人,硕士研究生,主治医师,研究方向:耳鼻喉科常见疾病诊治。
