摘要
目的探究丁苯酞联合尤瑞克林对大面积脑梗死患者血清神经生长因子及神经功能的影响。方法回顾性分析2020年3月—2022年9月我院收治的90例大面积脑梗死患者的临床资料,按治疗方式不同将患者分为对照组和观察组,每组45例。对照组在常规治疗基础上使用丁苯酞治疗,观察组在对照组基础上加用尤瑞克林治疗。对比两组美国国立卫生研究院卒中量表(NIHSS)量表评分、血清神经标志物、血清生长因子水平及不良反应发生情况。结果治疗后,观察组NIHSS评分为(6.05±1.99)分,低于对照组的(8.12±2.04)分,差异有统计学意义(P<0.05);观察组VILIP-1、NSE、S100B水平均低于对照组,组间差异有统计学意义(P<0.05);观察组VEGF、BDNF、IGF水平均高于对照组,组间差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论丁苯酞联合尤瑞克林能够改善大面积脑梗死患者的神经功能损伤情况,促进神经功能恢复,且安全性较高,值得临床推广使用。
Objective To investigate the effect of butylphthalide combined with urinary kallidinogenase on serum nerve growth factor and neurological function in patients with large-scale cerebral infarction.Methods A retrospective analysis was conducted on 90 patients with large-scale cerebral infarction admitted to our hospital from March 2020 to September 2022.They were divided into a control group and an observation group according to different treatment methods,with 45 cases in each group.The control group was treated with butylphthalide on the basis of routine treatment,while the observation group was treated with urokinase on the basis of the control group.Compare two sets of National Institutes of Health Stroke Scale(NIHSS)scores,serum neuromarkers,serum growth factor levels,and occurrence of adverse reactions.Results After treatment,the NIHSS score of the observation group was(6.05±1.99)points,which was lower than(8.12±2.04)points of the control group,and the difference was statistically significant(P<0.05);the levels of VILIP-1,NSE and S100B in observation group were lower than those in control group,and the differences between groups were statistically significant(P<0.05);the levels of VEGF,BDNF and IGF in observation group were higher than those in control group,and the differences between groups were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of butylphthalide and urinary kallidinogenase can improve the neurological damage in patients with large-scale cerebral infarction,promote neurological recovery,and have high safety,which is worthy of clinical promotion and use.
作者
史梓茜
SHI Ziqian(Department of Cerebrovascular Disease,Zibo Traditional Chinese Medicine Hospital,Zibo Shandong,255000,China)
出处
《反射疗法与康复医学》
2023年第14期123-125,144,共4页
Reflexology And Rehabilitation Medicine
关键词
大面积脑梗死
丁苯酞
尤瑞克林
血清神经生长因子
神经功能
Large area cerebral infarction
Butylphthalide
Yuriklin
Serum nerve growth factor
Neurological function
作者简介
史梓茜(1980-),女,山东淄博人,硕士研究生,主治医师,研究方向:神经系统疾病诊治。
