摘要
Objective:This study aimed to evaluate the association of ANRIL gene with atherosclerosis stroke(ATS)using single nucleotide polymorphism(SNP)in Han Chinese population;Methods:Han Chinese populations with ischemic stroke(IS)in Sichuan were chosen for this study using the case-control design from January 2012 to December 2013.The unrelated age-and sex-matched healthy controls were selected from volunteers accepting health examinations in the same hospital during the same period.The candidate gene association study design was employed to analyze the relationship of the ANRIL gene and ATS risk in entire samples and subgroup populations(sex and age(<45 or≥45 years)subgroups),and gene-enviromental interaction analyses were also carried out to get an insight of the risk factors for ATS;Results:200 cases with ATS and 205 healthy controls in all were entered into the final analyses.Dyslipidemia(OR=15.538,P<0.001 in overall people),AA genotype of rs2184061 and rs7044859 loci increased the risk for ATS in overall people(For rs2184061,OR=1.635,P=0.034;for rs7044859:OR=1.657,P=0.029)or≥45 years group(For rs2184061,OR=1.749,P=0.023;for rs7044859:OR=1.721,P=0.027).The AAAGAT haplotype were significantly associated with ATS risk in Men,Women or population aged 45 or older years(for Men:OR=4.697,P=0.0003;Women:OR=3.113,P=0.028;≥45 years:OR=3.376,P=0.0002).At the same,interaction of dyslipidemia,rs7044859 and rs10757269 polymorphism was related to ATS(P=0.0101);Conclusions:Dyslipidemia and ANRIL gene are associated with ATS risk in Han nationality of Chinese population.
基金
Key Projects of Sichuan Education Department(12ZA049).
作者简介
Corresponding author:Hua LIU,Department of Rehabilitation,Nanchong Central,Hospital&North Sichuan Medical College,Nanchong Sichuan,637000.,E-mail:45358307@qq.com
