摘要
目的探讨不同年龄人群中舒张压与颈动脉内中膜厚度的关联。方法以2010年—2018年参加开滦研究队列,并接受了颈动脉超声检查的人员23622例作为观察对象。根据世界卫生组织的年龄划分标准,将观察对象分为三组,即18~44岁组、45~59岁组和≥60岁组。采用多元线性逐步回归方法,分析不同年龄人群中舒张压(DBP)与颈动脉内中膜厚度(CIMT)的关联。结果观察对象的一般情况为2010年—2018年参加开滦研究队列,并接受颈动脉超声检查的观察对象共23622例,排除血压值缺失者219例和CIMT数据缺失者1754例,最终纳入统计分析者21649例。观察对象的年龄为(52.5±12.9)岁,其中男14883例(68.7%)。根据年龄将观察对象分为3组,其中18~44岁组5889例(27.2%),45~59岁组9077例(41.9%),≥60岁组6683例(30.9%)。不同年龄组CIMT值的分布及CIMI≥1.0 mm检出率情况:CIMT值与CIMI≥1.0 mm检出率随着年龄的增加而增加,18~44岁组、45~59岁组和≥60岁组人群CIMT的均数依次为0.72 mm、0.83 mm、0.96 mm(P<0.001),18~44岁组、45~59岁组和≥60岁组人群CIMT≥1.0mm检出率依次为4.9%、20.9%、49.6%(P<0.001)。CIMT相关因素的多元线性逐步回归分析结果显示,以CIMT为因变量,以DBP为自变量,校正了年龄、性别、心率、体重指数(BMI)、空腹血糖(FBG)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)、文化程度、吸烟、饮酒、体育锻炼、服降压药、服降糖药、服调脂药等混杂因素后,多元线性逐步回归分析结果显示,18~44岁组人群DBP与CIMTβ值=1.20,P<0.001,45~59岁组人群DBP与CIMTβ值=0.91,P<0.001,≥60岁组人群DBP未被纳入模型。结论在中青年人群中,DBP与CIMT呈正向关联,在老年人群中,DBP与CIMT无关联。
Objective To investigate the association of diastolic blood pressure and carotid intima-media thickness of various age groups.Methods Twenty-three thousand six hundred and twenty-two participants from the Kailuan study cohort who underwent carotid ultrasound from 2010 to 2018.According to the WHO criteria of age,participants were divided into 3 age groups:18-44 years group(n=5889),45-59 years group(n=9077),above 60 years group(n=6683).Multiple linear regression analysis was used to analyze the association between diastolic blood pressure(DBP)with carotid intima-media thickness(CIMT)in different age groups.Results The baseline characteristics of all participants,23622 participants underwent carotid ultrasound from 2010 to 2018.219 participants without blood pressure measurement values were excluded,1754 participants without CIMT measurement values were excluded.Data from 21649 participants were analyzed.The age was(52.5±12.9)years old,14883 were males(68.7%).The participants were divided into three groups according to their age,including 5889(27.2%)participants in 18 to 44 years old group,9077(41.9%)participants in 45 to 59 years old group and 6683(30.9%)participants in above 60 years old group.Distribution of CIMT values and detection rate of CIMT≥1.0 mm in various age groups,above bothincreased with aging.The mean value of CIMT in 18 to 44 years group,45-59 years group,above 60 years group were as follows:0.72,0.83,0.96 mm(P<0.001).The respective detection rate of CIMT≥1.0 mm were 4.9%,20.9%,49.6%(P<0.001).Multiple linear regression stepwise analysis defined risk factors of CIMT.Multivariate linear regression stepwise analysis showed that DBP was positively correlated with CIMT(β=1.20,P<0.001)in 18 to 44 years old group and(β=0.91,P<0.001)in 45 to 59 years group,above 60 years group DBP was not included in the model,after adjustment for other confounding factors,including age,sex,systolic blood pressure(SBP),body mass index(BMI),fasting blood glucose(FBG),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),hypersensitive C-reactive protein(hs-CRP).Conclusion The study found that DBP is positively related to CIMT in the young and middle-aged population,and DBP isn′t related to CIMT in the elderly population.
作者
李晓庆
李劼
张卫欢
陈朔华
黄玮
LI Xiaoqing;LI Jie;ZHANG Weihuan;CHEN Shuohua;HUANG Wei(Department of Ultrasonography,Kailuan General Hospital,Tangshan 063000,China)
出处
《中国煤炭工业医学杂志》
2021年第5期508-513,共6页
Chinese Journal of Coal Industry Medicine
基金
河北省医学科学研究重点课题计划项目(编号:20192112)
关键词
年龄
舒张压
颈动脉内中膜厚度
Age
Diastolic blood pressure
Carotid intima-media thickness
