摘要
Objective::To investigate the association of rs5210 in potassium voltage-gated channel subfamily J member 11(KCNJ11)with gestational diabetes mellitus(GDM).Methods::Six hundred and thirty-two uncorrelated pregnancy females were recruited in Tongji hospital from October 2017 to June 2018,in which 241 pregnant women were identified as GDM,and 391 were non-GDM.All the pregnant women recruited in this study their peripheral venous blood of 5 mL were withdrawn,and DNA in the blood was extracted.rs5210 in KCNJ11 were genotyped using TaqMan Assays and genotype models were analyzed using logistic regression analyses.Results::After adjusting age and body mass index,the variant genotypes of rs5210 in genotype models were as follows:P for dominant model was 0.945,(odd ratio:0.987,95%confidence intervals(CI):0.681-1.430);P for recessive model:0.556,(odd ratio:1.217,95%CI:0.633-2.343)and P for addictive model was 0.098(genotype AA vs.GG),(odds ratio:1.435,95%CI:0.936-2.201).Weight-gain during pregnancy and total cholesterol were significantly different in recessive model(P=0.015,P=0.022,respectively)of all participants.Conclusion::No significant association between gene susceptibility of rs5210 in KCNJ11 and GDM occurrence in Chinese pregnant women.But the variant of rs5210 was associated with weight-gain during pregnancy and total cholesterol blood levels.However,more cases are needed in genetic study to check its susceptibility with GDM occurrence in Chinese women.
基金
funded by the research grants from the National Key Research and Development Program of China(2016YFC1000405,2018YFC1002900)
the National Natural Science Foundation of China(41671497)
作者简介
Corresponding author:Prof.Ling Feng,Department of Obstetrics and Gynecology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei 430030,China.E-mail:fltj007@163.com
