摘要
目的探究结肠癌肝转移患者化疗前血清胆碱酯酶(cholinesterase,ChE)的水平与治疗的无进展生存时间之间(Progress Free Survival,PFS)的关系。方法回顾性收集从2014年2月到2019年7月在我院接受一线化疗的结肠癌肝转移患者病历资料和化疗前血清ChE的值。分析血清ChE对患者一线化疗PFS的预测价值。结果低PFS组患者的ChE(210.00±45.50 U/L)低于高PFS组(389.20±211.88)U/L,P=0.026。低ChE组患者的PFS(151.10±30.63)d明显低于高ChE组(242.80±58.22)d,P<0.001。患者血清ChE水平与治疗的PFS存在相关关系,Spearman相关系数为0.744,P<0.001。结论治疗前ChE水平对结肠癌肝转移患者化疗的PFS有预测作用,ChE水平越高,PFS越长。
Objective To explore the relationship between the level of serum cholinesterase(ChE)before chemotherapy and the progression free survival time(PFS)of colon cancer patients with liver metastasis.Methods Retrospectively collected medical records of colon cancer patients with liver metastases who received first-line chemotherapy from February 2014 to July 2019 in our hospital and the level of serum ChE before chemotherapy.To analyze the prognostic significance of serum ChE on patients with first-line chemotherapy.Results The level of serum ChE(210.00±45.50 U/L)in the low PFS group was lower than that in the high PFS group(389.20±211.88 U/L),P=0.026.The PFS(151.10±30.63 d)in the low ChE group was significantly lower than that of the high ChE group(242.80±58.22 d),P<0.001.There was a correlation between the level of serum ChE and the PFS.The Spearman correlation coefficient was 0.744,P<0.001.Conclusion The level of serum ChE before treatment has prognostic significance on PFS in colon cancer patients with liver metastasis.The higher the level of ChE,the longer the PFS.
作者
宗恒
汤雷
张艳
魏元东
ZONG Hen;TANG Lei(ZHANG Yan,et al.The Second People’s Hospital of Anhui,Hefei 230000,China)
出处
《肝胆外科杂志》
2020年第4期281-284,共4页
Journal of Hepatobiliary Surgery
关键词
胆碱酯酶
结肠癌
肝转移癌
疗效预测
cholinesterase
colon cancer
liver metastasis
prognostic significance
作者简介
通讯作者:汤雷。
