摘要
Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs)and clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPR-associated(Cas)nuclease systems.It is a promising tool for the development of new treatment strategies for infectious diseases.Due to its higher editing efficiency and lower off-target effect,gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections.Here,we reviewed the recent research progress of gene editing in antiviral therapy(human immunodeficiency virus,hepatitis B virus,severe acute respiratory syndrome coronavirus 2,and human papillomavirus)and inhibition of infectious diseases that involve bacteria,fungi and parasites.
基金
supported by the National Key R&D Program of China(2019YFA0109900,2019YFA0109901,2019YFA0802800,2019YFA0110803)
the Shanghai Municipal Commission for Science and Technology(19PJ1403500)
the National Natural Science Foundation of China(82270125)
作者简介
Corresponding author:Yuxuan Wu,email:yxwu@bio.ecnu.edu.cn
