摘要
目的分析慢性阻塞性肺疾病(COPD)并发肺部感染患者采用氨溴索联合左氧氟沙星治疗的效果。方法选择2018年9月—2023年8月济南市第三人民院收治的80例COPD并发肺部感染患者为研究对象,采用随机数字表法将其分为对照组及观察组,每组40例。对照组采用盐酸左氧氟沙星注射液治疗,观察组在对照组基础上采用盐酸氨溴索注射液治疗。对比两组患者的临床疗效、肺功能、炎症因子水平及不良反应发生情况。结果观察组的治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗后,观察组的用力肺活量、第1秒用力呼气容积均大于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的C反应蛋白、降钙素原、白细胞水平均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论COPD并发肺部感染患者接受氨溴索联合左氧氟沙星治疗,可提升临床疗效,改善肺功能,缓解炎症反应,且安全性良好。
Objective To analyze the effect of ambroxol combined with levofloxacin in patients with chronic obstructive pulmonary disease(COPD)complicated with pulmonary infection.Methods A total of 80 patients with COPD complicated with pulmonary infection admitted to Jinan Third People's Hospital from September 2018 to August 2023 were selected as the research objects,and were divided into a control group and an observation group by random number table method,with 40 cases in each group.The control group was treated with levofloxacin hydrochloride injection,and the observation group was treated with ambroxol hydrochloride injection on the basis of this.The clinical efficacy,lung function,levels of inflammatory factors and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.00%,higher than 80.00%of the control group,the difference was statistically significant(P<0.05).After treatment,the forced vital capacity and forced expiratory volume in one second in the observation group were greater than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of C-reactive protein,procalcitonin and white blood cells in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ambroxol combined with levofloxacin in patients with COPD complicated with pulmonary infection can improve clinical efficacy,improve lung function,relieve inflammation,and have good safety.
作者
郝玉佳
HAO Yujia(Department of Respiratory Medicine,Jinan Third People's Hospital,Jinan 250132,China)
出处
《反射疗法与康复医学》
2024年第9期94-96,100,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性阻塞性肺疾病
肺部感染
氨溴索
左氧氟沙星
肺功能
Chronic obstructive pulmonary disease
Pulmonary infection
Ambroxol
Levofloxacin
Lung function
作者简介
郝玉佳(1985-),女,山东济南人,硕士研究生,主治医师,研究方向:慢阻肺、感染性疾病治疗。
