摘要
目的:探讨维生素D辅助盐酸非索非那定片递减疗法治疗慢性荨麻疹(CU)的效果。方法:选取本院2018年5月~2020年5月收治的60例CU患者,随机分为观察组和对照组,各30例。对照组采取盐酸非索非那定片递减疗法,观察组在对照组基础上联合维生素D。比较两组总有效率、治疗前后的每日发作次数与每日发作时间、血清白细胞介素2(IL-2)、IL-4、IL-10、D二聚体(D-D)和纤维蛋白降解产物(FDP),记录不良反应发生率。结果:观察组总有效率90.00%,高于对照组66.67%。治疗后,两组每日发作次数、每日发作时间均较治疗前降低。观察组治疗后的每日发作次数、每日发作时间均低于对照组。治疗后,两组血清IL-2、25(OH)D高于治疗前,血清IL-4、IL-10、D-D、FDP低于治疗前。观察组治疗后的血清IL-2、25(OH)D高于对照组,血清IL-4、IL-10、D-D、FDP低于对照组。观察组和对照组不良反应发生率为6.67%和13.33%(4/30),差异无统计学意义。结论:维生素D辅助盐酸非索非那定片递减疗法治疗CU可改善凝血并发挥抗炎作用,有助于促进CU患者的恢复,疗效确切,安全性高。
Objective To explore the effect of vitamin D-assisted fexofenadine hydrochloride diminishing therapy in the treatment of chronic urticaria(CU).Methods A total of 60 CU patients admitted to our hospital from May 2018 to May 2020 were selected and randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with fexofenadine hydrochloride tablets,and the observation group was combined with vitamin D on the basis of the control group.The total effective rate,the number of daily attacks before and after treatment,and the daily attack time,serum interleukin 2(IL-2),IL-4,IL-10,D dimer(DD)and fibrin degradation products(FDP)were compared between the two groups.The incidence of adverse reactions were record.Results The total effective rate of the observation group was 90.00%,which was 66.67%higher than that of the control group.After treatment,the number of daily seizures and daily seizure time in the two groups were lower than before treatment.The number of daily seizures and daily seizure time of the observation group after treatment were lower than those of the control group.After treatment,the serum IL-2 and 25(OH)D of the two groups were higher than those before treatment,and the serum IL-4,IL-10,D-D,and FDP were lower than those before treatment.Serum IL-2 and 25(OH)D in the observation group were higher than those in the control group,and serum IL-4,IL-10,D-D,and FDP were lower than those in the control group.The incidence of adverse reactions in the observation group and the control group was 6.67%and 13.33%(4/30),and the difference was not statistically significant.Conclusion Vitamin D-assisted fexofenadine hydrochloride tablets diminishing therapy for CU can improve blood coagulation and exert anti-inflammatory effects,which can help promote the recovery of CU patients,with definite curative effect and high safety.
作者
熊坚癸
杨英杰
冯程程
Xiong Jian-gui;Yang Ying-jie;Feng Cheng-cheng(Department of Dermatology and Venereology,General Hospital of Wanbei Coal and Electricity Group,Anhui,Suzhou 234000,China)
出处
《湖南师范大学学报（医学版）》
2021年第4期262-265,共4页
Journal of Hunan Normal University(Medical Sciences)
关键词
慢性荨麻疹
维生素D
盐酸非索非那定片
递减疗法
凝血功能
免疫
抗炎
chronic urticaria
vitamin D
fexofenadine hydrochloride tablets
decrease therapy
blood coagulation
immunity
anti-inflammatory
作者简介
通讯作者:熊坚癸,E-mail:162141976@qq.com
