摘要
子宫内膜的蜕膜化是成功妊娠的关键,涉及到子宫内膜间质细胞的分泌能力、免疫细胞的选择性募集、多种免疫因子调节等。蜕膜化以间质细胞的内质网扩张、蛋白合成增加为主要特征,表现细胞生理性的内质网应激(ERS)、未折叠蛋白反应(UPR)。ERS和UPR相关信号分子可诱导激酶或核糖核酸酶表达,激活无菌性炎症反应、血管生成等生物学过程,有助于子宫内膜容受性的建立和维持。相反,ERS和UPR异常可能导致反复胚胎种植失败、反复流产、胎儿生长受限、子痫前期等问题。
Decidualization of endometrium involving secretion of endometrial stromal cells,selective recruitment of immune cells,and regulation of various immune factors,is the key to successful pregnancy.Decidualization is characterized by the expansion of endoplasmic reticulum and the increase of protein synthesis in stromal cells.It is characterized by physiological endoplasmic reticulum stress(ERS)and unfolded protein response(UPR).ERS and UPR related signaling molecules can induce the expression of kinase or ribonuclease,activate aseptic inflammatory response,angiogenesis and other biological processes,and contribute to the establishment and maintenance of endometrial receptivity.On the contrary,ERS and UPR abnormalities may lead to repeated embryo implantation failure,repeated abortion,fetal growth restriction,preeclampsia and other problems.
作者
伍谷
周鑫
韩磊
WU Gu;ZHOU Xin;HAN Lei(Department of Anesthesiology,the First People's Hospital of Chongqing Liangjiang New Area,Chongqing 401147;Department of Obstetrics and Gynecology,the First People's Hospital of Chongqing Liangjiang New Area,Chongqing 401147;Department of Reproductive Medicine,Affiliated Maternal and Child Health Care Hospital of Zunyi Medical University,Zunyi City 563099;Department of Obstetrics and Gynecology,Army characteristic medical center,Army Medical University,Chongqing 400042,China)
出处
《解剖科学进展》
CAS
2022年第6期782-785,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81401224)
遵义市科技计划项目(遵市科合HZ字[2020]271号)
遵义市红花岗区科技计划项目(遵红科合社字[2020]07号)
作者简介
通信作者:韩磊
