摘要
本实验应用免疫细胞化学和免疫电镜方法研究了大鼠脑血管壁的血管活性肠多肽(VIP)能神经支配。实验结果表明:VIP样免疫反应神经纤维位于血管壁外膜或外、中膜交界处。在神经末梢之间和神经末梢与平滑肌细胞之间未见突触结构。VIP末梢直接紧贴平滑肌细胞,两者间最小距离为100nm。上述结果表明:脑血管除传统的肾上腺素能和胆碱能神经支配外,还接受肽能神经支配。VIP神经对脑血管的调节作用可能借非突触释放直接作用于平滑肌而实现。此外,本文还证实了P物质(SP)在脑血管的分布及讨论了SP对脑血管的调节功能。
Using the immunohistochemical and immunoelectron microscopic methods,the localization and pattern of vasoactive intestinal polypeptidergic nerves in the wall of cerebral vessels were investigated.The results revealed that the VIP-like immunoreactive(VIPLI)fibres were located in the adventitia or at the adventitia-media border.No synaptic contacts were identified among the nerve terminals or between nerve terminal and smooth muscle cell.VIPLI terminals directly apposed to the smooth muscle cells with a distance of 100 nm.The observations mentioned above indicate that there is peptidergic innervation in the wall of the cerebral vessels besides traditional adrenergic and cholinergic innervations.The regulatory function of VIP-containing nerves to the cerebral vessels may be performed by affecting the smooth muscle directly through the nonsynaptic release.In addition,present study identified and discussed the distribution and function of substance P(SP)in the cerebral vessels.
作者
卢金活
朱长庚
刘庆莹
朱家祥
刘汉涛
陈阿青
Lu Jinbuo;Zhu Changgeng;Liu Qingying;Zhu Jiaxiang;Liu Hantao;Chen Aqing(Department of Anatomy,Tongji Medical University,Wuhan)
出处
《解剖学报》
CAS
1988年第2期148-151,227,共5页
Acta Anatomica Sinica
关键词
血管活性肠多肽
P物质
免疫组织化学
免疫电镜
脑血管
Vasoactive intestinal polypeptide
Substance P
Immunohistochemistry
Immunoelectron microscopy
Cerebral vessel
