摘要
新辅助放化疗联合全直肠系膜切除术已成为局部进展期直肠癌的标准治疗模式,多项研究显示新辅助放化疗可提高其病理完全缓解率、保肛手术率及局部控制率,但远处转移仍为主要死亡原因,总生存率未见明显获益。本文旨在提高临床医生对局部进展期直肠癌的认识,探讨不同放疗剂量分割模式及化疗方案对其的疗效。
Neoadjuvant chemoradiotherapy combined with total mesorectal excision(TME)has become the standard treatment mode for locally advanced rectal cancer.Many researches have demonstrated that neoadjuvant chemoradiotherapy can improve pathologic complete response(ypCR)rate,anal sphincter operation rate and local control rate,but distant metastasis is still the main cause of death and no significant benefit is found for the overall survival rate.This article aims to investigate the influence of different radiotherapy segmentation methods and dose distributions,and different chemotherapy regimens on clinical outcomes of locally advanced rectal cancer.
作者
刘璐
冯林春
LIU Lu;FENG Linchun(Department of Radiation Oncology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)
出处
《解放军医学院学报》
CAS
2020年第3期294-297,303,共5页
Academic Journal of Chinese PLA Medical School
基金
科技部国家重点研发计划(2016YFC0105700)
关键词
局部进展期直肠癌
新辅助放化疗
肿瘤治疗
locally advanced rectal cancer
neoadjuvant chemoradiotherapy
oncotherapy
作者简介
刘璐,女,在读硕士。研究方向:直肠癌新辅助放化疗。Email:liulu1101@163.com;通信作者:冯林春,男,主任医师,教授。Email:301flc@163.com
