摘要
目的探讨多囊卵巢综合征(PCOS)伴高雄激素血症(HA)患者中医体质分布规律及其与各项指标的相关性,为临床从辨体角度防治PCOS伴HA提供新思路。方法选取483名PCOS伴HA患者,采用频数分析、Logistic二元回归分析等统计方法,分析中医体质分布及与临床指标的相关性。结果PCOS伴HA患者以兼夹体质为主,其中以气虚、血瘀、湿热质为多见。年龄、体重、痤疮是气虚质的危险因素(P<0.05)。收缩压、卵泡刺激素(FSH)、游离三碘甲腺原氨酸(FT3)是湿热质的保护因素,痤疮、溢脂、空腹血糖(FPG)、载脂蛋白A(ApoA)、初潮年龄是湿热质的危险因素(P<0.05)。收缩压、总胆固醇(TC)、促甲状腺激素(TSH)是血瘀质的保护因素,痤疮、溢脂、甘油三酯(TG)、低密度脂蛋白(LDL)、ApoA是血瘀质的危险因素(P<0.05)。结论PCOS伴HA患者以气虚质、血瘀质及湿热质最常见,且不同体质与临床指标存在相关性。
Objective To explore the distribution of TCM constitution and its correlation with various indexes in patients with polycystic ovary syndrome(PCOS)complicated with hyperandrogenism(HA),so as to provide a new idea for clinical prevention and control of PCOS combined with HA from the perspective of syndrome identification.Methods A total of 483 patients with PCOS and HA were selected.The frequency analysis and logistic binary regression analysis were conducted to analyze the distribution of TCM constitution and its correlation with clinical indicators.Results Patients with PCOS and HA were mainly composed of jianjia constitution(one major constitution with manifestations of other constitution types),and qi deficiency,blood dampness and dampness-heat constitutions were more commonly-seen(P<0.05).Age,weight,and hemorrhoids were risk factors for qi deficiency constitution(P<0.05).Systolic blood pressure,Follicle-Stimulating Hormone(FSH)and Free Triiodothyronine(FT3)were protective factors whereas acne,fasting plasma glucose(GS),apolipoprotein a(ApoA)and menarche age were risk factors for dampness-heat constitution(P<0.05).Systolic blood pressure,total cholesterol(TC),and thyroid-stimulating hormone(TSH)were protective factorswhereasacne,lipid leaching,TG,low-density lipoprotein(LDL),and ApoA were risk factors for blood stasis constitution(P<0.05).Conclusion Among patients with PCOS with HA,qi deficiency,blood stasis and dampness-heat constitutions are most common,and constitutions are correlatedwith clinical indicators.
作者
杨艳婷
侯丽辉
李妍
Yang Yanting;Hou Lihui;Li Yan(Heilongjiang University of Chinese Medicine,Heilongjiang 150040;Department of Obstetrics and Gynecology,The First Affiliated Hospital,Heilongjiang University of Chinese Medicine)
出处
《现代中医临床》
2020年第1期30-34,共5页
Modern Chinese Clinical Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课(No.JDZX2012039)
国家中医药管理局全国名老中医药专家传承工作室建设项目(No.2014-9-10).
关键词
多囊卵巢综合征
高雄激素血症
体质
临床指标
相关性分析
polycystic ovary syndrome
hyperandrogenism
constitution
clinical indicators
correlation analysis
作者简介
杨艳婷,女,在读博士生;通信作者:侯丽辉,女,本科,主任医师、教授,博士生导师
