摘要
目的研究MRI征象联合血清糖类抗原125(CA125)对微血管浸润(MVI)阴性孤立性肝细胞肝癌(HCC)术后早期复发的预测价值。方法回顾性分析73例MVI阴性孤立性HCC患者术前MRI及临床资料,采用SPSS 20.0对术前MRI及临床资料与术后早期复发相关性进行分析。结果73例患者中,术后早期复发者20例,单因素分析结果示复发组与无复发组在性别、年龄、饮酒、肝硬化、肿瘤最大径、瘤内液化坏死、甲胎蛋白(AFP)值、病理分级、Ki-67水平及肝包膜侵犯之间比较差异无统计学意义(P>0.05);肿瘤边缘、肿瘤包膜及CA125值在两组间比较差异有统计学意义(P<0.05)。多因素分析结果示,肿瘤边缘及肿瘤包膜是MVI阴性孤立性HCC术后早期复发的独立影响因素(P均<0.05)。结论MRI征象及血清CA125对预测MVI阴性孤立性HCC患者术后早期复发具有重要价值。
Objective To investigate the predictive value of preoperative MR imaging features combined with serum CA125 level for early postoperative recurrence of MVI negative solitary hepatocellular carcinoma.Methods Preoperative MRI and clinical data of 73 patients with MVI negative solitary hepatocellular carcinoma in Guangxi medical university affiliated tumor hospital were collected.SPSS 20.0 was used to analyze the correlation between preoperative MRI,clinical data and early postoperative recurrence.Results Among 73 patients with MVI negative solitary hepatocellular carcinoma,20 had early postoperative recurrence.The differences of gender,age,alcohol consumption,cirrhosis,maximum tumor diameter,necrosis,AFP value,pathological grade,ki-67 level and liver capsule invasion between the recurrence group and the non-recurrence group were not statistically significant(P>0.05).While the differences of tumor margin,tumor capsule and serum CA125 level were statistically significant(P<0.05),multivariate analyses showed that tumor margins and tumor capsule were independent factors influencing the early postoperative recurrence of MVI negative solitary hepatocellular carcinoma(P<0.05).Conclusion Preoperative MR imaging features and serum CA125 level have great value in predicting early postoperative recurrence of MVI negative solitary hepatocellular carcinoma.
作者
韦云云
覃云英
廖海
张卫
苏丹柯
WEI Yunyun;QIN Yunying;LIAO Hai(Department of Radiology,Guangxi Medical University Cancer Hospital,Nanning,Guangxi Province 530021,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2020年第6期1113-1116,共4页
Journal of Clinical Radiology
基金
广西科技计划项目(编号:桂科AB18126031)
关键词
肝癌
磁共振成像
MVI阴性
早期复发
CA125
Hepatocellular carcinoma
MRI
MVI negative
Early postoperative recurrence
Serum CA125 level
作者简介
通讯作者:张卫;通讯作者:苏丹柯
