摘要
目的:探讨芪明颗粒联合氟米龙滴眼液治疗儿童中度干眼症的疗效及安全性。方法:选取2015年9月—2017年1月在本院进行治疗的儿童中度干眼症者84例作为本次研究对象,按随机数表法分为两组,各42例。对照组患者行氟米龙滴眼液治疗,观察组患者在对照组治疗基础上联合给予芪明颗粒进行治疗,比较两组患者的泪膜破裂时间(breakup time of tear film,BUT)、基础泪液分泌试验(schirmer I test,SIT)及角膜荧光染色评分(fluorescence staining,FLS)、疗效、眼表疾病指数(ocular surface disease index,OSDI)、结膜充血及睑板腺评分及不良反应情况。结果:治疗前,两组BUT、SIT及FLS比较,差异无统计学意义(P>0.05);治疗后,观察组FLS明显低于对照组,BUT、SIT较高,差异有统计学意义(P<0.05)。观察组患者的总有效率92.86%(39/42)明显高于对照组的69.05%(29/42),差异有统计学意义(P<0.05)。治疗前,两组睑板腺、结膜充血、OSDI评分比较,差异无统计学意义(P>0.05);治疗后,观察组睑板腺、结膜充血、OSDI评分均明显低于对照组,差异有统计学意义(P<0.05)。观察组眼睑总发生率4.76%(2/42),相比对照组患者的7.14%(3/42)差异无统计学意义(χ2=0.000,P>0.05)。结论:芪明颗粒联合氟米龙滴眼液可有效改善中度干眼症患儿临床症状,提高治疗效果,且安全性较好,值得临床应用推广。
Objective:To investigate the efficacy and safety of Qiming Granule combined with Fluoride Eye Drops in the treatment of moderate xerophthalmia in children.Methods:A total of 84 cases of patients with moderate xerophthalmia from September2015 to January 2017 in our hospital were selected as the objects of this study.All the patients were divided into two groups according to random number table method,each group 42 cases.In the control group,patients were treated with Fluoride Eye Drops and those in the observation group were treated with Qiming Granules on the basis of the control group.The levels of tear rupture(BUT),basal tear secretion test(SIT)and corneal fluorescence staining(FLS),efficacy,ocular surface disease index(OSDI),conjunctival hyperemia and meibomian gland score and adverse events were compared between the two groups.Results:There were no significant differences in BUT,SIT or FLS between the two groups before treatment(P>0.05).After treatment,FLS was significantly lower in the observation group than that in the control group.BUT and SIT were higher and the difference was statistically significant(P<0.05).The total effective rate was 92.86%(39/42)in the observation group and 69.05%(29/42)in the control group and the difference was statistically significant(P<0.05).There was no significant difference between the two groups in the treatment of tibial gland,conjunctival hyperemia and OSDI scores(P>0.05).After treatment,the observation group’s tarsal gland,conjunctival hyperemia and OSDI score were significantly lower than those of the control group and the difference was statistically significant(P<0.05).The overall incidence of eyelid in the observation group was 4.76%(2/42),which was not statistically significant(χ2=0.000,P>0.05)compared with 7.14%(3/42)in the control group.Conclusion:Qiming Granule combined with Fluoride Eye Drops can effectively improve the clinical symptoms of children with moderate xerophthalmia,improve the treatment effect and the safety is good.It is worthy of clinical application.
作者
李军
王健
王琴
LI Jun;WANG Jian;WANG Qin(Bijie Hospital of TCM,Bijie 551700,Guizhou,China)
出处
《辽宁中医杂志》
CAS
2019年第12期2609-2611,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
芪明颗粒
氟米龙滴眼液
儿童
中度干眼症
疗效
安全性
Qiming Granules
Fluoride Eye Drops
children
moderate xerophthalmia
efficacy
safety
作者简介
李军(1969-),男,副主任医师,学士,研究方向:眼科临床诊疗。;通讯作者:王健(1984-),男,主治医师,学士,研究方向:眼科临床诊疗。
