摘要
The present work describes the use of noninvasive diffuse optical tomography(DOT)technology to measure hemodynamic changes,providing relevant information which helps to understand the basis of neurophysiology in the human brain.Advantages such as portability,direct measurements of hemoglobin state,temporal resolution,non-restricted movements as occurs in magnetic resonance imaging(MRI)devices mean that DOT technology can be used in research and clinical fields.In this review we covered the neurophysiology,physical principles underlying optical imaging during tissue-light interactions,and technology commonly used during the construction of a DOT device including the source-detector requirements to improve the image quality.DOT provides 3 D cerebral activation images due to complex mathematical models which describe the light propagation inside the tissue head.Moreover,we describe briefly the use of Bayesian methods for raw DOT data filtering as an alternative to linear filters widely used in signal processing,avoiding common problems such as the filter selection or a false interpretation of the results which is sometimes due to the interference of background physiological noise with neural activity.
作者简介
Corresponding author:Esteania Hernandez‐Martin received her Ph.D.degree in healthy science from the University of La Laguna in 2018 focused on neuroimaging techniques in human brain.Her research focuses on signal processing,modeling,multivariate statistics and data interpretation for both electrophysiological and neuroimaging data sets.E‐mail:ehernanm@ull.edu.es;JoséLuis Gonzalez-Mora received his M.D.and Ph.D.degree from the University of La Laguna,Spain,in 1982 and 1987 respectively.He is a university professor(full)in 2011 and director of the Research Laboratory of Neurochemistry and Neuroimaging(LNN)since 1992,scientific director of the Institute of Neuroscience(IUNE)of the ULL since 2016.He is the author or co‐author of more than 180 international publications in the field of biomedicine and biomedical engineering.He has directed as a principal researcher or participated as a researcher in more than 42 national and international projects,including projects of the European community and he is member of several national and international scientific societies.E‐mail:jlgonzal@ull.edu.es
