摘要
目的通过回顾性病例对照研究,深入分析浆细胞性乳腺炎和肉芽肿性乳腺炎临床发病危险因素。方法通过回顾性病例对照研究,纳入浆细胞性乳腺炎患者132例和肉芽肿性乳腺炎患者182例,分别作为试验组,同期非乳腺疾患的中青年女性211例作为阴性对照组,以调查问卷的形式收集相关信息,通过多因素回归分析筛选浆细胞性乳腺炎和肉芽肿性乳腺炎各自的发病危险因素。结果浆细胞性乳腺炎患者与对照组相比较,在以下方面具有显著差异:平均年龄更小,距离产后时间更短,哺乳时长<6个月,具有乳头凹陷体征以及哺乳障碍史的比例更高(P<0.001);肉芽肿性乳腺炎患者与对照组相比较,在以下方面具有显著差异:平均体质量更大,体质量指数(BMI)超重者比例更高,距离产后时间更短(P<0.001),具有乳头凹陷体征、乳房外伤病史、伴有情绪障碍、具有口服避孕药物史的比例更高(P<0.001)。在进一步的多因素回归分析显示,浆细胞性乳腺炎的发病危险因素包括:哺乳时长<6个月(OR,2.028;P=0.012)、乳头凹陷(OR,0.136;P<0.001)、哺乳障碍史(OR,0.284;P=0.001);而肉芽肿性乳腺炎的发病危险因素包括:BMI指数≥24(OR,0.341;P=0.001)、乳头凹陷(OR,0.180;P<0.001)、口服避孕药物史(OR,0.280;P=0.008)。结论哺乳时长<6个月、乳头凹陷、哺乳障碍史是浆细胞性乳腺炎发病的危险因素;BMI指数≥24、乳头凹陷、口服避孕药是肉芽肿性乳腺炎发病的危险因素。
Objective Through the retrospective case-control study,to evaluate the clinical risk factors of plasma cell mastitis and granulomatous mastitis.Methods 132 plasma cell mastitis and 182 granulomatous mastitis were studied as positive group,and 211 average persons were studied as negative group.The clinical risk factors of plasma cell mastitis and granulomatous mastitis were founded through multivariate regression analysis.Results Compared with average persons,plasma cell mastitis were found that:the average age was younger,the time to postpartum was shorter,the proportion of the patients with breast-feeding time(<6 months)was higher,the signs of nipple depression and the lactation disorder was more common(P<0.001).Compared with average persons,granulomatous mastitis were found that:the average weight was larger,BMI and the proportion of overweight were higher,the time to postpartum was shorter(P<0.05).From the further multivariate regression analysis,it was found that,the risk factors of plasma cell mastitis was lactation time<6 months(OR,2.028;P=0.012),nipple depression(OR,0.136;P<0.001),and history of lactation disorder(OR,0.284;P=0.001).While,the risk factors of granulomatous mastitis was BMI index≥24 kg/m2(OR,0.341;P=0.001),nipple depression(OR,0.180;P<0.001),history of oral contraceptives(OR,0.280;P=0.008).Conclusion The risk factors of plasma cell mastitis is lactation time<6 months,nipple depression,and lactation disorder.While,the risk factors of granulomatous mastitis is BMI index≥24 kg/m2,nipple depression,and oral contraceptives.
作者
宋晓耘
周细秋
王玉
李锋
王瑞
郑金洲
SONG Xiaoyun;ZHOU Xiqiu;WANG Yu;LI Feng;WANG Rui;ZHENG Jinzhou(Pudong Branch,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《辽宁中医药大学学报》
CAS
2021年第11期138-142,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
上海市进一步加快中医药事业发展三年行动计划(ZY(2018-2020)-ZYBZ-01)
上海市中西医临床协作试点项目(ZXYXZ-201909)
上海龙华医院爱建捐赠基金(AJ047)
作者简介
宋晓耘(1984-),女,辽宁大连人,主治医师,硕士,研究方向:中医外科(甲乳方向);通讯作者:郑金洲(1981-),男,江苏盐城人,主治医师,博士,研究方向:外科(甲乳外科方向)。
