摘要
目的探讨糖尿病性骨质疏松患者骨代谢指标的变化及其影响因素。方法选取住院2型糖尿病患者218例,记录患者年龄、糖尿病病程、血糖控制水平;测定空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血钙(Ca)、血磷(P)、血碱性磷酸酶(ALP);测定身高、体重,计算体重指数(BMI);测定骨密度(BMD),记录相应的T、Z值。按骨密度结果分为骨质疏松组(A组),骨量减少组(B组),骨量正常组(C组)。结果骨质疏松在不同性别的检出率不同,女性患者骨质疏松的检出率大于男性(P<0.05);A、B组的年龄、病程、HbA1c明显大于C组(P<0.05);A组的FPG、ALP大于B、C组(P<0.05);A组的BMI低于B、C组(P<0.05);而3组间血Ca、血P差异无统计学意义(P>0.05)。结论糖尿病性骨质疏松患者骨代谢指标血Ca、血P无明显变化,而血ALP升高。年龄、FPG、HbA1c是骨质疏松的独立危险因素。
Objective To investigate the changes of bone metabolic markers and their influencing factors in patients with diabetic osteoporosis.Methods 218 patients with type 2 diabetes had been admitted their ages,durations of diabetes,hypoglycemic drugs and blood glucose control were inquired in detail.Fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1 c),blood calcium(Ca),blood phosphorus(P)and alkaline phosphatase(ALP)were measured.Their height and weight were measured and the body mass index(BMI)was calculated.Bone mineral density(BMD)was measured,the corresponding T and Z values were recorded.They were divided into an osteoporosis group(group A),osteopenia(group B)and bone mass normal group(group C)according to bone density.Results The detection rate of osteoporosis in different genders was different.The detection rate of osteoporosis in female patients was greater than that in men(P<0.05),the difference was statistically significant.The age and course of disease and HbA1 c in group A and B were significantly higher than those in group C(P<0.05).The FPG and ALP in group A were significantly higher than those in group B and C(P<0.05).The BMI in group A was lower than that of group B and C(P<0.05).There was no significant difference in Ca and P between the three groups(P>0.05).Conclusion There wasno significant change in the bone metabolism index Ca and P in the diabetic osteoporosis patients,while ALP increased.Age and FPG and HbA1 c were independent risk factors for osteoporosis.
作者
贺立侠
金秀平
刘佳明
万秋霞
He Li-xia;Jin Xiu-ping;Liu Jia-ming;Wan Qiu-xia(Department of Endocrinology,Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,Heibei,China)
出处
《兰州大学学报（医学版）》
CAS
2018年第6期45-49,共5页
Journal of Lanzhou University（Medical Sciences）
关键词
糖尿病性骨质疏松
骨代谢
血钙
血磷
碱性磷酸酶
diabetic osteoporosis
bone metabolism
blood calcium
blood phosphorusalkaline
phosphatase
作者简介
通信联系人:金秀平,女,主任医师,研究方向为内分泌与代谢学,e-mail:tnjxpp@126.com
