摘要
目的通过临床观察慢性粒细胞白血病(CML)慢性期(CML-CP)、急变期(CML-BP)患者及正常对照健康体检者血清中血管内皮生长因子(VEGF)的含量变化,探讨血管内皮生长因子与CML发病的关系。方法采用ELISA法,分别检测药物规范治疗1年后CML-CP(24例)、CML-BP(10例)患者和正常对照组(健康体检者10例)血清中VEGF的含量。结果与正常对照组健康体检者比较,CML-CP,CML-BP患者的血清VEGF含量明显增高,差异均有显著性(P<0.01),而规范治疗1年后CML-BP远高于CML-CP患者,差异均有显著性(P<0.05)。结论VEGF可成为CML病情评估一个独立的预后因素。
Objective To investigate the relationship between vascular endothelial growth factor(VEGF)and chronic myeloid leukemia(CML)prognosis by detecting the changes of VEGF in the serum of CML patients in the chronic phase(CML-CP)and bastic phase(CML-BP)compared with normal control subjects.Methods The drug was standardized for one year,and the changes of serum VEGF levels in patients with chronic CML(24 cases),acute disease patients(10 cases)and normal control group(10 healthy subjects)were detected by ELISA.Results Compared with the normal control group,serum VEGF levels in patients with CML-CP and CML-BP were significantly higher(P<0.05).Conclusion VEGF can be an independent prognostic factor for CML assessment.
作者
张利华
马军
邓军吉
ZHANG Lihua;MA Jun;DENG Junji(Department of Geriatrics,Traditional Chinese Medicine Hospital of Weifang,Weifang 261041,China;Department of Laboratory Medicine,Traditional Chinese Medicine Hospital of Weifang;Department of Hematology,Traditional Chinese Medicine Hospital of Weifang)
出处
《潍坊医学院学报》
2020年第1期75-77,共3页
Acta Academiae Medicinae Weifang
基金
潍坊市卫生和计划生育委员会中医药科研项目计划资助课题(课题编号:2018-1-008)
关键词
白血病
粒细胞
慢性
血管内皮生长因子
治疗
Chronic myeloid leukemia
Chronic
acute
Vascular endothelial growth factor
Therapy
作者简介
张利华(1979年~),男,主治医师,硕士学位。主要研究方向:老年病学,血液病;通讯作者:马军,E-mail:youyousanbu@163.com
