摘要
目的:分析益气活血法联合孟鲁司特钠治疗对慢性阻塞性肺气肿患者临床疗效、炎性因子及肺功能的影响。方法:回顾性分析2017年6月至2018年6月本院收治的60例慢性阻塞性肺气肿患者的临床资料,根据治疗方案,分为单一组(孟鲁司特钠治疗)和联合组(益气活血法联合孟鲁司特钠治疗),各30例。比较两组临床疗效、治疗前后炎性因子[白介素-6(Interleukin 6,IL-6)、白介素-8(Interleukin 8,IL-8)、肿瘤坏死因子(tumor necrosis factor-ɑ,TNF-ɑ)]水平、肺功能指标[测定用力肺活量(Fast vital capacity,FVC)、第1秒钟用力呼气容积(Forced expiratory volume in 1second,FEV1)、最大肺活量(Maximum vital capacity,MVC)、最大通气量(maximum minute ventilation,MMV)]变化及不良反应。结果:联合组治疗后总有效率(96.67%)显著高于单一组(80.00%)(P<0.05);治疗后,联合组炎性因子(IL-6、IL-8、TNF-ɑ)降低水平高于单一组,肺功能指标(FVC、FEV1、MVC、MMV)上升水平高于单一组(P<0.05);联合组不良反应发生率(13.33%)与单一组不良反应发生率(16.67%)比较无差异(P>0.05)。结果:益气活血法联合孟鲁司特钠治疗慢性阻塞性肺气肿可有效降低患者炎性因子水平,提高患者肺功能,临床疗效显著且安全性较高,具有临床使用价值。
Objective:To analyze the effect of Yiqi Huoxue Method combined with Montelukast Sodium on clinical efficacy,inflammatory factors and lung function for patients with chronic obstructive pulmonary emphysema.Methods:The clinical data of 60 patients with chronic obstructive pulmonary emphysema admitted to our hospital from June 2017 to June 2018 were retrospectively analyzed.According to the treatment plan,they were divided into a single group(montelukast sodium treatment)and a combined group(Yiqi Huoxue Method combined with Montelukast Sodium),30 cases in each group.The clinical efficacy,changes in inflammatory factors[Interleukin-6(IL-6),Interleukin-8(IL-8),tumor necrosis factor-ɑ(TNF-ɑ)],and pulmonary function indicators[Fast vital capacity(FVC),Forced expiratory volume in 1 second(FEV1),Maximum vital capacity(MVC),and maximum ventilation(Maximum minute ventilation,MMV)]and adverse reactions before and after treatment were compared between the two groups.Results:The total effective rate(96.67%)of the combined group after treatment was significantly higher than that of the single group(80.00%)(P<0.05).After treatment,the reduction of inflammatory factors(IL-6,IL-8,TNF-ɑ)in the combined group was higher than that of the single group,and the rising of lung function indexes(FVC,FEV1,MVC,MMV)was higher than that of the single group(P<0.05).There was no difference in the incidence of adverse reactions between the combined group(13.33%)and the single group(16.67%)(P>0.05).Conclusion:Applying Yiqi Huoxue Method combined with Montelukast Sodium in the treatment of chronic obstructive pulmonary emphysema can effectively reduce the level of inflammatory factors in patients and improve the lung function of patients.The clinical effect is significant and the safety is high.It has clinical value.
作者
李伟
LI Wei(Department of Medicine,Suixi County Hospital,Suixi Anhui 235000,China)
出处
《四川中医》
2022年第4期59-62,共4页
Journal of Sichuan of Traditional Chinese Medicine
关键词
益气活血法
孟鲁司特钠
慢性阻塞性肺气肿
临床疗效
炎性因子
肺功能
Yiqi Huoxue Method
Montelukast sodium
Chronic obstructive emphysema
Clinical efficacy
Inflammatory factors
Lung function
