摘要
目的探讨系统性红斑狼疮(SLE)及抗磷脂抗体综合征(APS)并发颅内静脉窦血栓形成(CVST)的临床表现、诊断及治疗方法。方法分析1例SLE、APS合并CVST患者的病例资料,并进行文献复习。结果该病例为32岁青年女性,以头痛、发热为主要临床表现,颅脑MRV考虑CVST,SLE、APS相关抗体阳性,该患者病程中先后经历多种类型发热,经抗感染、抗凝、降颅压、预防癫痫、激素治疗原发病后病情好转。结论SLE、APS合并CVST较为罕见,因其临床症状不典型,易发生漏诊,临床上对不明原因出现头痛、癫痫发作、局灶性脑损害的患者应尽早完善颅脑MRI/MRV检查及风湿系列抗体筛查。
Objective To investigate the clinical manifestations,diagnosis and treatment of systemic lupus erythematosus(SLE)and antiphospholipid syndrome(APS)complicated with cerebral venous sinus thrombosis(CVST).Methods The clinical data of the patient were analyzed,and relevant literature was reviewed.Results The patient was a 32-year-old woman with headache and fever as the main clinical manifestations.Brain MRV indicated CVST.Antibodies related to SLE and APS were positive.The patient successively experienced fever with different origins during the course of the disease.Her condition was improved after anti-infection,anticoagulation,intracranial pressure reduction,epilepsy prevention,and hormone therapy for the primary disease.Conclusion SLE and APS complicated with CVST are rare.Due to the atypical clinical symptoms,missed diagnosis is easy to occur.Brain MRI/MRV and antibody screening should be performed as soon as possible in patients with unexplained headache,seizures and local brain damage.
作者
成晅
杨帆
潘正论
CHENG Xuan;YANG Fan;PAN Zhenglun(Department of Rheumatology,Qilu Hospital of Shandong University(Qingdao),Qingdao 266035,Shandong,China)
出处
《山东大学学报（医学版）》
CAS
北大核心
2022年第6期70-74,共5页
Journal of Shandong University:Health Sciences
作者简介
通信作者:潘正论。E-mail:panzhenglun@126.com
