摘要
近年来,肥胖患病率日益增长,但其机制未明,建立合适的动物模型是研究其发病机制的重要方法,而动物模型的稳定性和可重复性十分关键。通过对肥胖大鼠模型研究的文献回顾,分析相关影响因素,本研究认为在造模时应选用离乳3-4周龄雄性Wistar大鼠;饲料配方在营养素和能量比例平衡的基础上,考虑口感及成型;喂食过程中需要结合大鼠摄食规律,并注意大鼠对高脂饲料的适应和肥胖抵抗因素对模型建立的影响;而造模持续时间应根据实际研究目的来确定,以期为相关研究有所裨益。
In recent years,the prevalence of obesity is increasing,but its mechanism is not clear,establishing an appropriate animal model is an important method to study its pathogenesis,and the stability and repeatability of animal models are crucial.This review summarizes the study of diet-induced obese rat models and analysis of influenced factors,it is suggested that the weaning male Wistar rats of 3-4 weeks old should be selected for the establishment of models,based on the balance of nutrients and energy,the formula should takes into account taste and molding,during the feeding process,it is necessary to combine the feeding pattern of rats,and pay attention to the adaptation of rats to high-fat diet and the effect of obesity-resistant on the establishment of models,the duration of modelling should be determined by the research purpose,in order to benefit the relevant research.
作者
姚俊鹏
周思远
陈丽萍
张林
李瑛
Yao Junpeng;Zhou Siyuan;Chen Liping;Zhang Lin;Li Ying(College of Acupuncture and Massage,Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China;Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Diabetes Mellitus Prevention and Control Center of Sichuan Province,Chengdu,610041,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2165-2172,共8页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上项目(81673803):基于Tsc1-mTOR甲基化修饰介导自噬探讨电针减肥效应差异化机制研究,负责人:张林
关键词
肥胖
大鼠模型
影响因素
综述
Obesity
Rat model
Influenced factors
Review
作者简介
通讯作者:李瑛,教授,博士,主要研究方向:针刺治疗内分泌代谢疾病的机制研究。
