摘要
目的:评价长春西汀联合石杉碱甲片用于老年血管性痴呆症的疗效及对缺氧诱导因子-1α(HIF-1α)、抗凋亡因子(Livin)和血管内皮生长因子(VEGF)水平的影响。方法:98例老年血管性痴呆症患者依据简单随机法分为对照组(n=51)和研究组(n=47),对照组采用长春西汀治疗,研究组在对照组基础上联合石杉碱甲片治疗,比较两组临床疗效,治疗前后简易精神状态评价量表(MMSE)、哈金斯基(Hachiaski)缺血量表(HIS),HIF-1α、Livin和VEGF水平,血液流变学指标,以及药物不良反应发生情况。结果:治疗后,研究组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组MMSE、HIS评分,HIF-1α、Livin和VEGF水平,血液流变学指标比较差异无统计学意义(P>0.05);治疗后,两组MMSE、Livin和VEGF水平较治疗前显著上升,HIS评分、HIF-1α水平和血液流变学指标较治疗前显著下降,研究组以上指标变化更明显,差异均有统计学意义(均P<0.05)。两组不良反应发生情况比较差异无统计学意义(P>0.05)。结论:长春西汀联合石杉碱甲片治疗老年血管性痴呆症的疗效显著,可明显改善患者认知功能,调节HIF-1α、Livin及VEGF水平。
Objective:To evaluate the efficacy of vinpocetine combined with huperzine tablets in senile vascular dementia and the effect on the levels of hypoxia inducible factor-1α(HIF-1α),anti-apoptotic factor(Livin)and vascular endothelial growth factor(VEGF).Methods:98 cases of senile vascular dementia patients were divided into control group(n=51)and research group(n=47)according to the simple random method,the control group was treated with vinpocetine,and the research group was treated with huperzine tablet on the basis of the control group.The clinical curative effect,mini-mental state examination(MMSE),Hachiaski ischemia scale(HIS),levels of HIF-1α,Livin and VEGF,hemorheology index before and after the treatment,and the occurrence of adverse drug reactions in both group were compared.Results:After treatment,the total effective rate of the research group was higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in MMSE,HIS scores,levels of HIF-1α,Livin and VEGF,and hemorheology index between the two groups(P>0.05).After treatment,MMSE,levels of Livin and VEGF in the two groups were increased significantly compared with those before treatment,while HIS score,levels of HIF-1αand hemorheology indexes were decreased significantly compared with those before treatment,and the above indexes in the research group showed more significant changes,the difference was statistically significant(all P<0.05).There was no statistically significant difference in the occurrence of adverse reactions between the two groups(P>0.05).Conclusion:Vinpocetine combined with huperzine tablet has a significant effect on the treatment of senile vascular dementia,which can significantly improve the cognitive function of patients and regulate the levels of HIF-1α,Livin and VEGF.
作者
李强
赵伟丽
孙会艳
李林林
王金刚
LI Qiang;ZHAO Wei-li;SUN Hui-yan;LI Lin-lin;WANG Jin-gang(Department of Neurology,Affiliated Hospital Of Chifeng University,Chifeng,Inner Mongolia,024005,China;Judicial Expertise Center,Affiliated Hospital Of Chifeng University,Chifeng,Inner Mongolia,024005,China;Integrated Office,Affiliated Hospital Of Chifeng University,Chifeng,Inner Mongolia,024005,China)
出处
《现代生物医学进展》
CAS
2019年第23期4569-4573,共5页
Progress in Modern Biomedicine
基金
内蒙古自治区高校基金项目(NJZY16249).
关键词
老年血管性痴呆症
长春西汀
石杉碱甲片
疗效
缺氧诱导因子-1α
抗凋亡因子
血管内皮生长因子
Senile vascular dementia
Vinpocetine
Huperzine tablet
Curative effect
Alpha hypoxia inducible factor-1α
Anti-apoptotic factor
Vascular endothelial growth factor
作者简介
李强(1980-),男,硕士,副主任医师,研究方向:脑血管病,电话:15847351095,E-mail:dblo87659@163.com;通讯作者:孙会艳(1981-),女,博士,副主任法医师,研究方向:法医临床
