摘要
目的对莫哈韦丝兰的化学成分进行系统研究,以增强其植物资源开发力度,扩大其临床应用范围。方法综合应用多种色谱方法,如大孔吸附树脂、硅胶、Sephadex LH-20、ODS以及高效液相法对莫哈韦丝兰的化学成分进行分离纯化,并利用理化性质与核磁共振波谱数据鉴定它们的结构。结果从莫哈韦丝兰70%乙醇提取物中分离鉴定了8个化合物,分别为:丁香脂素(1)、(-)-丁香脂素-4-O-β-D-吡喃葡萄糖苷(2)、(-)-开环异落叶松脂酚(3)、异落叶松脂素(4)、threo guaiacyglycerol-8′-vannillic acid ether(5)、山柰酚(6)、槲皮素(7)、双氢山柰酚(8)。结论化合物1-5和8为首次从该属植物中分离得到。
Objective To complete the chemical study of Yucca schidigera Roezl(Mojave) systematically,as well as to enhance the development of the plant resources and clinical application of it.Methods The compounds from Y.schidigera were isolated by chromatographic methods such as D101 resin,silica gel,Sephadex LH-20,ODS and HPLC,and the structures are elucidated by their physicochemical properties and spectral data.Results Eight compounds were isolated and identified as syringaresinol(1),(-)-syringaresinol 4-O-β-D-glucopyranoside(2),(-)-secoisolariciresinol(3),isolariciresinol(4),threo guaiacyglycerol-8′-vannillic acid ether(5),kaempferol(6),quercetin(7),(2R,3R)-dihydro kaempferol(8),respectively.Conclusion Compounds 1-5 and 8 were obtained from Yucca genus firstly.
作者
王剑丽
瞿璐
阮静雅
郑丹丹
孙璠
张祎
WANG Jianli;QU Lu;RUAN Jingya;ZHENG Dandan;SUN Fan;ZHANG Yi(Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2020年第2期126-130,共5页
Journal of Shenyang Pharmaceutical University
基金
国家自然基金资助项目(81673688).
关键词
莫哈韦丝兰
化学成分
结构鉴定
Yucca schidigera Roezl(Mojave)
chemical constituents
structure identification
作者简介
王剑丽(1992-),女(汉族),黑龙江人,硕士研究生,E-mail wjl15802226160@126.com;通信作者:张祎(1974-),女(汉族),河北唐山人,教授,博士,主要从事药效物质基础研究,Tel.022-59596163,E-mail zhwwxzh@263.net。
